Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22663
Abstract: Imidazo[1,2‐a]pyridines (IP) and organoselenium compounds have been widely exploited in medicinal chemistry due to their pharmacological activities. Hepatocellular carcinoma (HCC) has few treatment options, and unfortunately, the prognosis is poor. Thus, the development of novel… read more here.
Keywords: hepatocellular carcinoma; cells vivo; apoptosis oxidative; hepg2 cells ... See more keywords
A Review on the Assessment of Imidazo[1,2-a]pyridines As Corrosion Inhibitor of Metals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bio- and Tribo-Corrosion"
DOI: 10.1007/s40735-018-0207-3
Abstract: Imidazo[1,2-a]pyridines find great importance in several commercially available drugs but recently, this derivative has been reported as effective corrosion inhibitors due to their excellent excited state intra-molecular proton transfer which elevates the performances of their… read more here.
Keywords: review assessment; pyridines corrosion; assessment imidazo; corrosion ... See more keywords
Au-catalyzed domino process synthesis of imidazo[1,2-a]pyridines from 2-aminopyridine and N-tosylhydrazones: An efficient CN bond formation reaction
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DOI: 10.1016/j.catcom.2016.10.033
Abstract: Abstract A novel Au-catalyzed domino reaction for the synthesis of imidazo[1,2- a ]pyridines from 2-aminopyridine and N-tosylhydrazones has been developed using molecular oxygen. It represents a new strategy for the formation of C N bonds.… read more here.
Keywords: aminopyridine tosylhydrazones; pyridines aminopyridine; catalyzed domino; synthesis imidazo ... See more keywords
Nitrosylation of imidazo[1,2-a]pyridines in metal free system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2016.02.004
Abstract: Abstract An efficient nitrosylation of imidazo[1,2- a ]pyridines has been developed using tert-Butyl nitrite (TBN) as the NO resource. The nitrosylation protocol demonstrates broad compatibilities, with various functional groups such as halogen, Me, OMe, COOMe… read more here.
Keywords: nitrosylation; pyridines metal; metal free; imidazo pyridines ... See more keywords
Oxone®-mediated direct arylselenylation of imidazo[2,1-b]thiazoles, imidazo[1,2-a]pyridines and 1H-pyrazoles
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.06.046
Abstract: Abstract Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylselanyl-imidazo[1,2-a]pyridines and 4-arylselanyl-1H-pyrazoles… read more here.
Keywords: mediated direct; oxone mediated; imidazo; direct arylselenylation ... See more keywords
Electrochemical [4 + 1] Tandem sp3(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
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DOI: 10.1021/acsomega.1c06029
Abstract: 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide… read more here.
Keywords: imidazo pyridines; tandem sp3; sp3 double; double amination ... See more keywords
I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo00063h
Abstract: An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and TBHP as an… read more here.
Keywords: acylated imidazo; dehydrogenative aminooxygenation; aminooxygenation alkynes; pyridines indolizines ... See more keywords
Pd-catalyzed annulation of imidazo[1,2-a]pyridines with coumarins and indoles: synthesis of benzofuran and indole fused heterocycles.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06803b
Abstract: Palladium-catalyzed annulation of imidazo[1,2-a]pyridines with coumarins provided benzofuran fused transannulated products in good to excellent yields via a decarbonylative approach, while imidazo[1,2-a]pyridines with N-methyl indoles in the presence of palladium and base yielded conjugated imidazopyridine… read more here.
Keywords: imidazo pyridines; catalyzed annulation; pyridines coumarins; imidazo ... See more keywords
Microwave-assisted copper(i) catalyzed A3 cascade coupling of imidazo[1,2-a]pyridines via C–H bond functionalization as selective COX-2 inhibitors and antioxidants, and in silico studies
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj00524k
Abstract: A proficient copper(i) catalyzed one pot synthetic protocol has been established to synthesize medicinally essential substituted imidazo[1,2-a]pyridines via C–H bond amination followed by acetylene incorporation under microwave irradiation. read more here.
Keywords: imidazo pyridines; copper catalyzed; pyridines via; via bond ... See more keywords
Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4063470
Abstract: Herein, the design, synthesis and mechanistic study of five series of imidazo[1,2-a]pyridines 8a-d, 9a-f, 11a-c, 12a-d and 14a-d as anticancer agents were discussed. The cytotoxicity of imidazo[1,2-a]pyridine derivatives was screened against NCI 60 cancer cell… read more here.
Keywords: design synthesis; cell; imidazo pyridines; leukemia 562 ... See more keywords
In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179645
Abstract: The ionotropic GABAA receptor (GABAAR) has been proven to be an important target of atypical antipsychotics. A novel series of imidazo [1,2-a]-pyridine derivatives, as selective positive allosteric modulators (PAMs) of α1-containing GABAARs with potent antipsychotic… read more here.
Keywords: gabaa receptor; imidazo pyridines; screening novel; silico screening ... See more keywords