Synthesis and Antimicrobial Activity Evaluation of Amide and Sulfonamide Derivatives Containing Imidazo[2,1‐b][1,3,4]thiadiazole moiety
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DOI: 10.1002/ajoc.202500028
Abstract: A series of amides (19a–i) and another of sulfonamides (21a–g) containing the imidazo[2,1‐b][1,3,4]thiadiazole moiety were synthesized and evaluated for their antimicrobial activities. Most of these compounds showed good antibacterial activities (MIC = 4–64 μg/mL). Compounds… read more here.
Keywords: imidazo thiadiazole; containing imidazo; synthesis antimicrobial; antimicrobial activity ... See more keywords
Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐b][1,3,4]thiadiazole Analogues
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DOI: 10.1002/cmdc.202100122
Abstract: Three series of new imidazole‐fused imidazo[2,1‐b][1,3,4]thiadiazole analogues (compounds 20 a–g, 21 a–g, and 22 a–g) have been synthesized, and their antibacterial and antifungal activities have been evaluated. All the target compounds showed strong antifungal activity and high selectivity… read more here.
Keywords: imidazo thiadiazole; fused imidazo; thiadiazole analogues; activity ... See more keywords
Synthesis and antitubercular evaluation of imidazo[2,1-b][1,3,4]thiadiazole derivatives
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DOI: 10.1016/j.arabjc.2013.01.001
Abstract: Abstract In the present study, a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives 5(a–j) were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral technique. The compounds were evaluated for their in vitro antitubercular activity… read more here.
Keywords: imidazo thiadiazole; antitubercular evaluation; synthesis antitubercular; thiadiazole derivatives ... See more keywords
Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability.
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DOI: 10.1016/j.bioorg.2017.11.021
Abstract: A series of imidazo[2,1-b][1,3,4]thiadiazole linked indolinone conjugates were synthesized and investigated for antiproliferative activity in different human cancer cell lines by changing various substitutions at indolinone and phenyl ring systems. Among them conjugates 7, 14… read more here.
Keywords: imidazo thiadiazole; microtubule network; apoptosis; linked indolinone ... See more keywords
Discovery and Evaluation of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives as New Candidates for α-Synuclein PET Imaging.
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DOI: 10.1021/acs.jmedchem.4c00686
Abstract: α-synuclein (α-syn) pathologies are central to the development of synucleinopathies including Parkinson's disease (PD). Positron emission tomography (PET) imaging of α-syn pathologies is one strategy to facilitate the diagnosis, understanding, and treatment of synucleinopathies, but… read more here.
Keywords: pet imaging; imidazo thiadiazole; syn pathologies; discovery evaluation ... See more keywords