Construction of benzo[d]imidazo[2,1-b]thiazole derivatives via a simple multi-component domino cyclization
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3123-0
Abstract: An operationally simple and highly efficient one-pot multi-component domino cyclization for the preparation of benzo[d]imidazo[2,1-b]thiazole derivatives from 2-amine-benzo[d]thiazoles, 2-oxoaldehyde and cyclic 1,3-dicarbonyl compounds under microwave irradiation has been developed in this work. Formation of the… read more here.
Keywords: imidazo thiazole; domino cyclization; component domino; multi component ... See more keywords
Synthesis and biological evaluation of imidazo[2,1-b]thiazole-benzimidazole conjugates as microtubule-targeting agents.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.02.005
Abstract: A series of imidazo[2,1-b]thiazole-benzimidazole conjugates were synthesized and evaluated for their antiproliferative activity against four human cancer cell lines i.e.; HeLa (cervical), A549 (lung), MCF-7 (breast) and DU-145 (prostate) along with normal HEK-293 cell line.… read more here.
Keywords: thiazole benzimidazole; benzimidazole conjugates; cell; imidazo thiazole ... See more keywords
Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents
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DOI: 10.1021/acsomega.9b02789
Abstract: Noscapine, a phthalide isoquinoline alkaloid isolated from the opium poppy Papaver somniferum, is traditionally being used as an anticough drug. With a safe in vitro toxicological profile, noscapine and its analogues have been explored to… read more here.
Keywords: imidazo thiazole; natural noscapine; thiazole coupled; coupled natural ... See more keywords
Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03318f
Abstract: In the search for new anti-mycobacterial agents, we revealed the importance of imidazo-[2,1-b]-thiazole and benzo-[d]-imidazo-[2,1-b]-thiazole carboxamide derivatives. We designed, in silico ADMET predicted and synthesized four series of novel imidazo-[2,1-b]-thiazole and benzo-[d]-imidazo-[2,1-b]-thiazole carboxamide analogues in… read more here.
Keywords: imidazo thiazole; thiazole carboxamide; benzo imidazo;