Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABAA receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103334
Abstract: Structure-activity relationship studies were conducted in the search for 1,3-thiazole isosteric analogs of imidazopyridine drugs (Zolpidem, Alpidem). Three series of novel γ-aminobutyric acid receptor (GABAAR) ligands belonging to imidazo[2,1-b]thiazoles, imidazo[2,1-b][1,3,4]thiadiazoles, and benzo[d]imidazo[2,1-b]thiazoles were synthesized and… read more here.
Keywords: allosteric modulators; development thiazole; development; imidazo thiazoles ... See more keywords
Oxone®-mediated direct arylselenylation of imidazo[2,1-b]thiazoles, imidazo[1,2-a]pyridines and 1H-pyrazoles
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.06.046
Abstract: Abstract Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylselanyl-imidazo[1,2-a]pyridines and 4-arylselanyl-1H-pyrazoles… read more here.
Keywords: mediated direct; oxone mediated; imidazo; direct arylselenylation ... See more keywords
Synthesis of Thiazole Linked Imidazo[2,1-b]Thiazoles as Anticancer Agents
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DOI: 10.1080/10406638.2019.1689514
Abstract: Abstract Based on the search for new heterocyclic drugs suitable as anticancer agents and our knowledge of the efficacy of thiazol and imidazothiazole derivatives as anticancer drugs, we have created four new series of thiazolylimidazothiazole… read more here.
Keywords: anticancer agents; thiazoles anticancer; linked imidazo; synthesis thiazole ... See more keywords