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   Articles with "imidazol methyl" as a keyword



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New 7-piperazinylquinolones containing (benzo[d]imidazol-2-yl)methyl moiety as potent antibacterial agents

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recommendations! Published in 2018 at "Molecular Diversity"

DOI: 10.1007/s11030-018-9834-3

Abstract: A series of 7-piperazinylquinolones containing a (benzo[d]imidazol-2-yl)methyl moiety were designed and synthesized as new antibacterial agents. The antibacterial activity of title compounds was evaluated against Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and Gram-negative… read more here.

Keywords: antibacterial agents; containing benzo; benzo imidazol; imidazol methyl ... See more keywords
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Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPARĪ³ agonists.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2016.11.051

Abstract: In this structure-activity relationship study, the influence of aryl substituents at position 5 or 6 on the pharmacological profile of the partial PPARĪ³ agonist 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid was investigated. This lead was previously identified as the… read more here.

Keywords: ppar; pharmacological profile; benzo imidazol; imidazol methyl ... See more keywords
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Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor

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recommendations! Published in 2019 at "Bioinformatics and Biology Insights"

DOI: 10.1177/1177932219865533

Abstract: Plasmodium falciparum adenylosuccinate lyase (PfADSL) is an important enzyme in purine metabolism. Although several benzimidazole derivatives have been commercially developed into drugs, the template design as inhibitor against PfADSL has not been fully explored. This… read more here.

Keywords: benzo imidazol; plasmodium falciparum; imidazol methyl; adenylosuccinate lyase ... See more keywords