A single amino acid substitution converts a histidine decarboxylase to an imidazole acetaldehyde synthase.
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DOI: 10.1016/j.abb.2020.108551
Abstract: Histidine decarboxylase (HDC; EC 4.1.1.22), an enzyme that catalyzes histamine synthesis with high substrate specificity, is a member of the group II pyridoxal 5'-phosphate (PLP) -dependent decarboxylase family. Tyrosine is a conserved residue among group… read more here.
Keywords: histidine decarboxylase; decarboxylase; amino acid; acetaldehyde synthase ... See more keywords