Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300047
Abstract: In this work, we extend the concept of 5‐fluorouracil/heme oxygenase 1 (5‐FU/HO‐1) inhibitor hybrid as an effective strategy for enhancing 5‐FU‐based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI… read more here.
Keywords: imidazole based; oxygenase inhibitor; mutual prodrugs; heme oxygenase ... See more keywords
Chemoselective Palladium‐Catalyzed Direct C–H Arylation of 5‐Carboxyimidazoles: Unparalleled Access to Fused Imidazole‐Based Tricycles Containing Six‐, Seven‐ or Eight‐Membered Rings
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700297
Abstract: An extensive study of the chemoselective Pd-catalyzed inter- and intramolecular direct C–H arylation of N-benzylated 5-carboxyimidazoles with halides with and without CuI assistance in 1,4-dioxane as a low-polarity solvent was explored. The method was suitable… read more here.
Keywords: direct arylation; membered rings; fused imidazole; eight membered ... See more keywords
Comparison of the efficiency of two imidazole-based dicationic ionic liquids as the catalysts in the synthesis of pyran derivatives and Knoevenagel condensations
Sign Up to like & getrecommendations! Published in 2019 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-019-03874-5
Abstract: In the present work, 3,3′-(butane-1,4-diyl)bis(1-methyl-1H-imidazol-3-ium) dichloride ([C4(MIm)2]·2Cl) and 3,3′-(butane-1,4-diyl)bis(1-methyl-1H-imidazol-3-ium) hydrogen sulfate ([C4(MIm)2]·2HSO4) were prepared via adequate, solvent-free methods and characterized using FT-IR, 1H NMR, 13C NMR, and potentiometric titration techniques. These reagents were investigated in… read more here.
Keywords: efficiency two; comparison efficiency; two imidazole; based dicationic ... See more keywords
A simple and easy-to-prepare imidazole-based probe for the selective chromo-fluorogenic recognition of biothiols and Cu(II) in aqueous environments
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.10.017
Abstract: Abstract A new simple and easy-to-prepare imidazole-based probe 1 was synthesized and used to detect Cu(II) and biothiols (Cys, Hcy and GSH) in aqueous environments. Addition of increasing amounts of Cu(II) to water (pH 7.4)-acetonitrile… read more here.
Keywords: based probe; easy prepare; prepare imidazole; probe ... See more keywords
A new V-shaped 2H-imidazole-based spirocyclic fluorophore: Aggregation-induced emission, twisted intramolecular charge transfer, and high responsiveness to trace water and acid
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109640
Abstract: Abstract Design and synthesis of organic solid-state emissive materials have attracted wide attentions due to their potential applications in organic light-emitting diodes (OLEDs), chemo-/bio-sensing, organic lasers, electronic ink, etc. Herein, a V-shaped 2H-imidazole-based spirocyclic fluorophore,… read more here.
Keywords: water; emission; shaped imidazole; imidazole based ... See more keywords
Chronic toxicity of treated and untreated aqueous solutions containing imidazole-based ionic liquids and their oxydized by-products.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.05.048
Abstract: In the present work, an experimental study is presented aimed at assessing the chronic toxicity of three imidazole-based ionic liquids, i.e. imidazole (IM), 1-methylimidazole (1MIM), 1-ethyl-3-methyl-imidazolium chloride (1E3MIM), and 1-butyl-3-methyl-imidazolium chloride (1B3MIM), generally considered as… read more here.
Keywords: imidazole based; chronic toxicity; toxicity; ionic liquids ... See more keywords
Acenaphthene-imidazole based red-to-NIR Emissive Homoleptic and Heteroleptic Ir(III) complexes for OLEDs: Combined experimental and theoretical approach
Sign Up to like & getrecommendations! Published in 2021 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2021.120268
Abstract: Abstract A series of homoleptic and heteroleptic Iridium(III) complexes (Ir-1–Ir-4) bearing on acenaphthene-imidazole have been successfully designed and synthesized. The photophysical properties of these complexes were examined with appropriate spectroscopic methods. The results, in combination… read more here.
Keywords: red nir; acenaphthene imidazole; homoleptic heteroleptic; iii complexes ... See more keywords
Fluorescence quenching study of new coumarin-derived fluorescent imidazole-based chemosensor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114316
Abstract: Abstract In this study, we report a new coumarin-based fluorescent sensor (CUM-P10) for sensitive detection of different inorganic quenchers (halide ions, aromatic amines or transition metal ions). The CUM-P10 copolymer was obtained through a post-synthesis… read more here.
Keywords: cum p10; fluorescence quenching; new coumarin; fluorescence ... See more keywords
Exploring magnetic particle surface embedded with imidazole-based deep eutectic solvent for diclofenac removal from pharmaceutical wastewater samples
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115809
Abstract: Abstract This article described the use of imidazole-based deep eutectic solvents (DES) as functionalization agent for magnetic particles (Fe3O4) to form novel adsorbent and its application for diclofenac removal from pharmaceutical wastewater samples. A DES… read more here.
Keywords: pharmaceutical wastewater; surface; wastewater samples; imidazole based ... See more keywords
An Imidazole-Based Triangular Macrocycle for Visual Detection of Formaldehyde.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c03118
Abstract: Highly selective detection of formaldehyde utilizing supramolecules has promising applications in both environmental monitoring and biomonitoring areas. Herein we present a new class of imidazole-based, coordination-driven, self-assembled triangular macrocycles with specific recognition of formaldehyde. The… read more here.
Keywords: detection formaldehyde; detection; imidazole based; based triangular ... See more keywords
Nitric Oxide Reactivity of a Cu(II) Complex of an Imidazole-Based Ligand: Aromatic C-Nitrosation Followed by the Formation of N-Nitrosohydroxylaminato Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b00069
Abstract: A binuclear Cu(II) complex, 1, [Cu2(L-)2(OAc)](OAc) of imidazole-based ligand LH {LH = 2-(bis(2-ethyl-5-methyl-1H-imidazol-4-yl)methyl)phenol} was synthesized and characterized spectroscopically and structurally. Addition of an equivalent amount of nitric oxide (NO) by a gastight syringe to the… read more here.
Keywords: methyl; nitrosohydroxylaminato complex; based ligand; nitric oxide ... See more keywords