The role of imidazole and benzimidazole heterocycles in Chagas disease: A review.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112692
Abstract: The haemoflagellate protozoan Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), a potentially life-threatening disease. Little by little, remarkable progress has been achieved against CD, although it is still not enough. In… read more here.
Keywords: imidazole benzimidazole; chemistry; chagas disease; role imidazole ... See more keywords
Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole.
Sign Up to like & getrecommendations! Published in 2017 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2017-0236
Abstract: Metalloporphyrin heme oxygenase (HO) inhibitors have made an important contribution to elucidating the role of HO in physiological processes. Nevertheless, their off-target effects have drawn substantial criticism, which prompted us to develop non-porphyrin, azole-based inhibitors… read more here.
Keywords: imidazole benzimidazole; heme oxygenase; rat; inhibition ... See more keywords
Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity
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DOI: 10.4155/fmc-2019-0063
Abstract: Aim: Over the last decades, few significant achievements have been made in tuberculosis (TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new classes of bis-(imidazole/benzimidazole)-pyridine derivatives were… read more here.
Keywords: antimycobacterial activity; bis imidazole; benzimidazole pyridine; imidazole benzimidazole ... See more keywords