Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure–activity relationship
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DOI: 10.1007/s00436-020-06668-6
Abstract: Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii . Limitations of available treatments motivate the search for better therapies for toxoplasmosis. In this study, we synthesized a series of new imidazole derivatives: bis… read more here.
Keywords: derivatives antiparasitic; imidazole derivatives; structure activity; imidazoles compounds ... See more keywords
Iron–Phosphonate Nanomaterial: As a Novel and Efficient Organic–Inorganic Hybrid Catalyst for Solvent-Free Synthesis of Tri-Substituted Imidazole Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inorganic and Organometallic Polymers and Materials"
DOI: 10.1007/s10904-020-01530-9
Abstract: In this study, organic–metal nanocatalyst was synthesized by reacting ferric(ΙΙ) chloride with organic phosphonate ligand. The particle size was controlled with the help of the surfactant. Nanoparticle structure was analyzed using Fourier transform infrared (FT-IR),… read more here.
Keywords: iron phosphonate; phosphonate nanomaterial; imidazole derivatives; catalyst ... See more keywords
Thermal, spectral and biological investigation of new nickel complexes with imidazole derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7133-y
Abstract: Four new Ni(II) complexes with acrylate and imidazole (Him) or imidazole derivatives [2-methylimidazole(2-MeIm)/5-methylimidazole(5-MeIm)/2-ethylimidazole(2-EtIm)] as ligands were prepared and characterized. All coordination compounds were characterized by elemental analysis, infrared (FTIR) and ultraviolet-visible-near-infrared (UV-Vis-NIR) spectroscopy, mass spectroscopy,… read more here.
Keywords: imidazole derivatives; spectral biological; spectroscopy; thermal spectral ... See more keywords
Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103277
Abstract: Mutations in bacteria can result in antibiotic resistance due to the overuse or abuse of β-lactam antibiotics. One strategy which bacteria can become resistance toward antibiotics is secreting of metallo β-lactamase enzymes that can open… read more here.
Keywords: imp; investigation inhibitory; imidazole derivatives; synthesis investigation ... See more keywords
Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives.
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DOI: 10.1016/j.bioorg.2020.104020
Abstract: New imidazolidindiones and tetra-substituted imidazole derivatives were designed, synthesized, and evaluated for the anticonvulsant activity through pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) tests using valproate sodium and phenytoin sodium as reference drugs, respectively. Most… read more here.
Keywords: design synthesis; anticonvulsant activity; imidazole derivatives; synthesis anticonvulsant ... See more keywords
Imidazole derivatives as corrosion inhibitors for copper: A DFT and reactive force field study
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DOI: 10.1016/j.corsci.2020.108724
Abstract: Abstract We have investigated the corrosion inhibition mechanisms of imidazole, adenine, purine and 6-benzylaminopurine for copper using density functional theory (DFT) and reactive force fields (ReaxFF). The computed quantum chemical descriptors and interaction energy magnitudes… read more here.
Keywords: derivatives corrosion; dft reactive; imidazole derivatives; corrosion ... See more keywords
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.060
Abstract: In our previous study, we reported a series of 1-hydroxy-2-phenyl-1H-imidazole-5-carboxylic acid derivatives that presented excellent in vitro xanthine oxidase inhibitory potency. As a continuation study, a series of 1-hydroxy-2-phenyl-1H-imidazole derivatives containing a pyridine moiety (4a-g and… read more here.
Keywords: xanthine oxidase; imidazole derivatives; series; oxidase inhibitors ... See more keywords
Synthesis of s-triazine based tri-imidazole derivatives and their application as thermal latent curing agents for epoxy resin
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DOI: 10.1016/j.matlet.2017.12.122
Abstract: Abstract A series of novel s-triazine based tri-imidazole derivatives were successfully prepared through the substitution reaction of cyanuric chloride with imidazole (IM), 2-methylimidazole (2MI), 2-ethylimidazole (2EI) and 2-ethyl-4-methylimidazole (EMI), respectively. The synthesized tri-imidazole derivatives were… read more here.
Keywords: epoxy resin; imidazole derivatives; based tri; tri imidazole ... See more keywords
Modeling the conformational preference, spectroscopic properties, UV light harvesting efficiency, biological receptor inhibitory ability and other physico-chemical properties of five imidazole derivatives using quantum mechanical and molecular mechanics tools
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.112871
Abstract: Abstract Five imidazole derivatives, 1-boc-imidazole (B1), 1-(trifluoroacetyl)imidazole (B2), 1-(2-hydroxyethyl)imidazole (B3), 1-(aminopropyl)imidazole (B4) and 1-ethylimidazole (B5) were analyzed for the structural, nonlinear optical, electronic and biological properties. The functional nature of the compounds were analyzed using… read more here.
Keywords: five imidazole; preference spectroscopic; conformational preference; modeling conformational ... See more keywords
Understanding reactivity of two newly synthetized imidazole derivatives by spectroscopic characterization and computational study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.01.029
Abstract: Abstract Two newly synthetized imidazole derivatives (1-(4-methoxyphenyl)-4,5-dimethyl-1H-imidazole-2-yl acetate (MPDIA) and 1-(4-bromophenyl)-4,5-dimethyl-1H-imidazole-2-yl acetate (BPDIA)) have been prepared by solvent-free synthesis pathway and their specific spectroscopic and reactive properties have been discussed based on combined experimental and… read more here.
Keywords: synthetized imidazole; newly synthetized; understanding reactivity; imidazole derivatives ... See more keywords