Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase.
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DOI: 10.1016/j.bioorg.2019.03.074
Abstract: A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a could effectively inhibit PTP1B… read more here.
Keywords: imidazole flavonoids; phosphatase; tyrosine phosphatase; protein tyrosine ... See more keywords