Imidazole propionate ameliorates lipid metabolism in adipocytes to attenuate high-fat diet-induced obesity via PPAR signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-025-02768-3
Abstract: Obesity is a global health concern linked to metabolic disorders and gut microbiota dysbiosis, particularly under high-fat diet (HFD) conditions. This study explores the role of imidazole propionate (ImP), a histidine-derived microbial metabolite, in regulating… read more here.
Keywords: ppar; lipid metabolism; obesity; fat diet ... See more keywords
Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
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DOI: 10.1186/s13073-024-01296-6
Abstract: Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. We performed shot-gun sequencing on… read more here.
Keywords: imp; etiology; gut microbiota; severity ... See more keywords
Imidazole Propionate is Increased in Diabetes and Associated with Stool Consistency
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s362715
Abstract: Background Imidazole Propionate (ImP) is a new marker of Type 2 diabetes mellitus (T2DM), which can induce impaired glucose metabolism and weaken the efficacy of metformin. An extensive exploration into literature suggests that ImP may… read more here.
Keywords: consistency; group; imidazole propionate; imp ... See more keywords
Imidazole propionate ameliorates atopic dermatitis-like skin lesions by inhibiting mitochondrial ROS and mTORC2
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1324026
Abstract: Background Imidazole propionate (IMP) is a histidine metabolite produced by some gut microorganisms in the human colon. Increased levels of IMP are associated with intestinal inflammation and the development and progression of cardiovascular disease and… read more here.
Keywords: like skin; imp; inhibiting mitochondrial; skin lesions ... See more keywords
Ginsenoside Compound K Ameliorates Development of Diabetic Kidney Disease through Inhibiting TLR4 Activation Induced by Microbially Produced Imidazole Propionate
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112863
Abstract: Diabetic kidney disease (DKD) is a common and devastating complication in diabetic patients, which is recognized as a large and growing problem leading to end-stage kidney disease. As dietary-mediated therapies are gradually becoming more acceptable… read more here.
Keywords: kidney; ginsenoside compound; imidazole propionate; kidney disease ... See more keywords