Controllable access to multi-substituted imidazoles via palladium(ii)-catalyzed C-C coupling and C-N condensation cascade reactions.
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DOI: 10.1039/c7cc05315k
Abstract: A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C-C coupling followed by intramolecular C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles… read more here.
Keywords: imidazoles via; cascade; palladium catalyzed; catalyzed coupling ... See more keywords
Efficient Conversion of Tertiary Propargylamides into Imidazoles via Hydroamination-Cyclization
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DOI: 10.1055/s-0036-1591599
Abstract: A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to… read more here.
Keywords: efficient conversion; propargylamides imidazoles; conversion tertiary; via hydroamination ... See more keywords
Synthesis of 2,4-Disubstituted Imidazoles via Nucleophilic Catalysis
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DOI: 10.1055/s-0039-1690832
Abstract: A convergent, microwave-assisted protocol for the synthesis of disubstituted NH-imidazoles via nucleophilic catalysis is described. The substituted imidazoles are accessed via the intramolecular addition of a variety of amidoxime substrates to activated alkynes followed by… read more here.
Keywords: via nucleophilic; nucleophilic catalysis; disubstituted imidazoles; synthesis disubstituted ... See more keywords