Novel benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives as potential Anti-Alzheimer's agents: Synthesis and Pharmacological investigations.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00403
Abstract: A series of N-benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives were synthesized and evaluated for anti-Alzheimer's activity. The analogs were designed and synthesized based on lead compound donepezil, which is currently prescribed as a major drug for… read more here.
Keywords: benzylated pyrrolidin; one imidazolidin; pyrrolidin one; imidazolidin one ... See more keywords
Crystal structure, Hirshfeld surface analysis and PIXEL calculations of a 1:1 epimeric mixture of 3-[(4-nitrobenzylidene)amino]-2(R,S)-(4-nitrophenyl)-5(S)-(propan-2-yl)imidazolidin-4-one
Sign Up to like & getrecommendations! Published in 2019 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989019013938
Abstract: A 1:1 epimeric mixture of 2(R,S)-(4-nitrophenyl)-3-[(4-nitrobenzylidene)amino]-5(S)-(propan-2-yl)imidazolidin-4-one was derived from an initial reaction of 2(S)-amino-3-methyl-1-oxobutanehydrazine at its hydrazine moiety to provide a 4-nitrobenzylidine derivative, followed by a cyclization reaction with another molecule of 4-nitrobenzaldehyde to form… read more here.
Keywords: imidazolidin one; amino; epimeric mixture; nitrobenzylidene amino ... See more keywords