Design, synthesis, biological evaluation and molecular dynamics simulation studies of imidazolidine-2,4-dione derivatives as novel PTP1B inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.047
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood… read more here.
Keywords: molecular dynamics; imidazolidine dione; dione derivatives; dynamics simulation ... See more keywords
Exploring the Effects of Chirality of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl) phenyl]imidazolidine-2,4-dione and its Derivatives on the Oncological Target Tankyrase 2. Atomistic Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230330084017
Abstract: BACKGROUND Tankyrases (TNKS) are homomultimers existing in two forms, viz. TNKS1 and TNKS2. TNKS2 plays a pivotal role in carcinogenesis by activating the Wnt//β-catenin pathway. TNKS2 has been identified as a suitable target in oncology… read more here.
Keywords: phenyl imidazolidine; quinazolin phenyl; imidazolidine dione; oxo quinazolin ... See more keywords