Activation of imidazoline receptor I2, and improved pancreatic β-cell function in human islets.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2018.06.010
Abstract: AIM The impact of BL11282, an imidazoline receptor (NISCH) agonist, on potentiation of glucose-stimulated insulin secretion (GSIS) from isolated human non-diabetic (ND) and type 2 diabetic (T2D) islets was investigated. METHODS Analysis of mRNA was… read more here.
Keywords: bl11282; imidazoline receptor; camp; human islets ... See more keywords
Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-κB Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004065
Abstract: OBJECTIVES The knowledge that agmatine is found in the human body has existed for several years; however, its role in sepsis has not yet been studied. In the present study, we investigate the role of… read more here.
Keywords: agmatine; kinase; sepsis; imidazoline receptor ... See more keywords
Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor
Sign Up to like & getrecommendations! Published in 2023 at "Aging Cell"
DOI: 10.1111/acel.13774
Abstract: Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature to caloric restriction and identified… read more here.
Keywords: caloric restriction; rilmenidine; caenorhabditis elegans; imidazoline receptor ... See more keywords
CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14845
Abstract: CR4056 is a first‐in‐class imidazoline‐2 (I2) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced pain in patients with knee… read more here.
Keywords: cr4056 powerful; translocation; imidazoline receptor; receptor ligand ... See more keywords
Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15478
Abstract: The development of effective therapeutic strategies against Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a neuroprotective role in AD. Moreover, co‐treatment of AChE inhibitors with neuroprotective agents have shown better effects… read more here.
Keywords: alzheimer disease; treatment; imidazoline receptor; disease ... See more keywords
Thymoquinone activates imidazoline receptor to enhance glucagon-like peptide-1 secretion in diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Medical Science"
DOI: 10.5114/aoms.2019.86938
Abstract: Thymoquinone (TQ) is one of the principal bioactive ingredients proven to exhibit anti-diabetic effects. Recently, glucagon-like peptide-1 (GLP-1) has been found to be involved in antidiabetic effects in rats. The aim of this study was… read more here.
Keywords: glp; like peptide; secretion; imidazoline receptor ... See more keywords