New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling study.
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DOI: 10.1016/j.bioorg.2019.103438
Abstract: New imidazol-5-one derivatives 12a,b and 12e, f, 14a,b and 16a,b were synthesized and screened for their in vivo anti-inflammatory activity using a standard acute carrageenan-induced rat paw oedema method. All the tested compounds exhibited good… read more here.
Keywords: anti inflammatory; dhfr; tested compounds; imidazolone derivatives ... See more keywords