Dissection of the Enzymatic Process for Forming a Central Imidazopiperidine Heterocycle in the Biosynthesis of a Series c Thiopeptide Antibiotic.
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DOI: 10.1021/jacs.1c05956
Abstract: Thiopeptide antibiotics are a family of ribosomally synthesized and posttranslationally modified peptide natural products of significant interest in anti-infective agent development. These antibiotics are classified into five subfamilies according to differences in the central 6-membered… read more here.
Keywords: enzymatic process; series; imidazopiperidine heterocycle; series thiopeptide ... See more keywords