Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
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DOI: 10.1039/c6md00564k
Abstract: Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated with imidazopyridine… read more here.
Keywords: structural changes; imidazopyridine diacylglycerol; dgat2 inhibitors; small structural ... See more keywords