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Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201701194
Abstract: In the last years, imine reductases (IREDs) have gained importance for the formation of chiral amines by catalyzing asymmetric reductions of imines and chemo‐ and stereoselective reductive aminations. However, all characterized members of this steadily…
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Keywords:
imine reductase;
cofactor specificity;
switching cofactor;
specificity imine ... See more keywords
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Published in 2017 at "ChemCatChem"
DOI: 10.1002/cctc.201701379
Abstract: Chiral secondary and tertiary amines are ubiquitous in pharmaceutical, fine, and specialty chemicals, but their synthesis typically suffers from significant sustainability and selectivity challenges. Biocatalytic alternatives, such as enzyme‐catalyzed reductive amination, offer several advantages over…
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Keywords:
aminations extending;
imine reductase;
biocatalytic reductive;
efficient biocatalytic ... See more keywords
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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01274
Abstract: A new imine reductase from Stackebrandtia nassauensis (SnIR) was identified, which displayed over 25- to 1400-fold greater catalytic efficiency for 1-methyl-3,4-dihydroisoquinoline (1-Me DHIQ) compared to other imine reductases reported. Subsequently, an efficient SnIR-catalyzed process was…
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Keywords:
imine reductase;
reductase;
identification imine;
reduction bulky ... See more keywords