The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
Sign Up to like & getrecommendations! Published in 2022 at "Chemcatchem"
DOI: 10.1002/cctc.202201126
Abstract: Imine reductases (IREDs) are NADPH‐dependent enzymes with significant biocatalytic potential for the synthesis of primary, secondary, and tertiary chiral amines. Their applications include the reduction of cyclic imines and the reductive amination of prochiral ketones.… read more here.
Keywords: discovery imine; reductases utilisation; synthesis; synthesis tetrahydroisoquinolines ... See more keywords
Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00802
Abstract: Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99%… read more here.
Keywords: pharmaceutically relevant; aryl substituted; substituted pyrrolidines; imine reductases ... See more keywords
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemistry"
DOI: 10.1038/s41557-020-00606-w
Abstract: Finding faster and simpler ways to screen protein sequence space to enable the identification of new biocatalysts for asymmetric synthesis remains both a challenge and a rate-limiting step in enzyme discovery. Biocatalytic strategies for the… read more here.
Keywords: diverse panel; imine reductases; reductive amination;
One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases
Sign Up to like & getrecommendations! Published in 2017 at "Green Chemistry"
DOI: 10.1039/c6gc03023h
Abstract: Imine reductases (IREDs) show great potential as catalysts for reductive amination of ketones to produce chiral secondary amines. In this work, we explored this potential and synthesized the pharmaceutically relevant (R)-rasagiline in high yields (up… read more here.
Keywords: rasagiline; imine reductases; reductive amination; one step ... See more keywords