Domino Imino-Aldol-Aza-Michael and Imino-Aldol-Aza-Michael-Imino-Aldol Reactions: Diastereoselective Synthesis of Highly Functionalized 2,6-Disubstituted Piperidines
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DOI: 10.1016/j.tet.2021.132285
Abstract: Abstract Enolate mediated domino imino-aldol-aza-Michael and domino imino-aldol-aza-Michael-imino-aldol reactions of α-(aryl/alkyl)methylidene-β-diketones with activated N-aryl aldimines (1.0 and 2.0 equiv., respectively) have been developed for the diastereoselective (de >99%) synthesis of two sets of highly functionalized… read more here.
Keywords: imino aldol; michael imino; imino; aza michael ... See more keywords