Synthesis of 4,7-Difunctionalized Indoles via Imino Exchange and Sulfinyl Migration.
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DOI: 10.1021/acs.orglett.9b04257
Abstract: A process that rapidly assembles 4,7-difunctionalized indoles from 2-alkynycyclohexadienimines, sulfinamides, and nucleophiles (amines or alcohols) was developed. The process involves imino exchange, cascade cyclization/1,4-nucleophilic addition/aromatization, and 1,3-migration of the sulfinyl group. The 7-sulfinyl group is… read more here.
Keywords: imino exchange; difunctionalized indoles; synthesis difunctionalized; migration ... See more keywords