Hypervalent Iodine Reagents Enable C-H Alkynylation with Iminophenylacetic Acids via Alkoxyl Radicals.
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DOI: 10.1021/acs.orglett.2c02210
Abstract: Here we report δ-C-H alkynylation to synthesize various δ-alkynols from iminophenylacetic acids. The hypervalent iodine-coordinated benziodoxole-alkoxyl-iminophenylacetic acid complex was the key intermediate and was characterized by X-ray crystallography for the first time. δ-C-H alkynylation is… read more here.
Keywords: reagents enable; hypervalent iodine; alkynylation; iodine reagents ... See more keywords
Hypervalent Iodine Reagents Enable C(sp2)-H Amidation of (Hetero)arenes with Iminophenylacetic Acids.
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DOI: 10.1021/acs.orglett.2c02751
Abstract: Sulfonamide-containing (hetero)arenes are widely present in bioactive molecules. Here, we report the sulfonamidyl (hetero)arenes synthesis by the C(sp2)-H amidation from bench-stable amidyl-iminophenylacetic acids. The hypervalent iodine reagents covalently activated iminophenylacetic acids for the facile sulfonamidyl… read more here.
Keywords: hypervalent iodine; iodine reagents; iminophenylacetic acids; hetero arenes ... See more keywords