An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve‐agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.425
Abstract: ABSTRACT We have recently shown that the pyridinium aldoximes, best‐known as therapeutic antidotes for chemical warfare nerve‐agents, could markedly detoxify the carcinogenic tetrachloro‐1,4‐benzoquinone (TCBQ) via an unusual double Beckmann fragmentation mechanism. However, it is still… read more here.
Keywords: radical homolysis; tcbq; iminyl radical; normal physiological ... See more keywords
Synthesis of gem-Disulfonyl Enamines via an Iminyl-Radical-Mediated Formal 1,3-HAT/Radical Coupling Cascade.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02277
Abstract: We herein report the first example of an iminyl-radical-mediated formal 1,3-HAT/radical coupling cascade of vinyl azides leading to the synthesis of tetrasubstituted gem-disulfonyl enamines. It is possible to employ a variety of vinyl azides and… read more here.
Keywords: mediated formal; iminyl radical; hat radical; radical coupling ... See more keywords
Visible-Light Photoredox-Catalyzed Iminyl Radical Formation by N-H Cleavage with Hydrogen Release and Its Application in Synthesis of Isoquinolines.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00193
Abstract: An unprecedented visible-light photoredox-catalyzed iminyl radical formation by N-H cleavage with H2 release has been developed. Its application in the synthesis of various isoquinolines and related polyaromatics in high atom economy at ambient temperature by… read more here.
Keywords: iminyl radical; light photoredox; visible light; catalyzed iminyl ... See more keywords
Iminyl-Radical-Mediated Formation of Covalent Au-N Bonds for Molecular Junctions.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00453
Abstract: The interaction between organic radicals and transition metals plays a crucial role in radical-mediated chemical reactions, functional devices, and biocatalysis. Characterizing such interactions, however, remains a long-standing challenge due to the inherently high reactivity of… read more here.
Keywords: covalent bonds; iminyl radical; radical mediated; mediated formation ... See more keywords
Iminyl radical-promoted imino sulfonylation, imino cyanogenation and imino thiocyanation of γ,δ-unsaturated oxime esters: synthesis of versatile functionalized pyrrolines
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c9qo00421a
Abstract: We reported an iminyl radical-promoted imino-functionalization of γ,δ-unsaturated oxime esters to synthesize versatile functionalized pyrrolines. read more here.
Keywords: radical promoted; unsaturated oxime; promoted imino; imino ... See more keywords
Metal-free iminyl radical-mediated C–C single bond cleavage/functionalization of redox-active oxime esters
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01446b
Abstract: A visible-light-driven iminyl radical-mediated C–C bond cleavage and functionalization of cycloketone oxime esters have been accomplished. This protocol is simple and does not require expensive and toxic photoredox and/or transition-metal catalysis, providing a novel catalyst-free… read more here.
Keywords: iminyl radical; oxime esters; bond cleavage; radical mediated ... See more keywords