Cost-Effectiveness of Imipenem/Cilastatin/Relebactam Compared with Colistin in Treatment of Gram-Negative Infections Caused by Carbapenem-Non-Susceptible Organisms
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DOI: 10.1007/s40121-022-00607-x
Abstract: Imipenem/cilastatin/relebactam (IMI/REL), a combination β-lactam antibiotic (imipenem) with a novel β-lactamase inhibitor (relebactam), is an efficacious and well-tolerated option for the treatment of hospitalized patients with gram-negative (GN) bacterial infections caused by carbapenem-non-susceptible (CNS) pathogens.… read more here.
Keywords: imipenem; imi rel; cost; cms imi ... See more keywords
Imipenem–Relebactam and Meropenem–Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations
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DOI: 10.1007/s40265-017-0851-9
Abstract: Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase inhibitor that is structurally related to avibactam, differing by the addition of a piperidine ring to the 2-position carbonyl group. Vaborbactam (formerly known as… read more here.
Keywords: imipenem; vaborbactam; imipenem relebactam; meropenem vaborbactam ... See more keywords
Pharmacokinetic and Pharmacodynamic Analysis of Critically Ill Patients Undergoing Continuous Renal Replacement Therapy With Imipenem.
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DOI: 10.1016/j.clinthera.2020.06.010
Abstract: PURPOSE This study explores factors that affect behavior in critically ill patients receiving continuous renal replacement therapy (CRRT) with imipenem and provides dosing regimens for these patients. METHODS A prospective, open-label study was conducted in… read more here.
Keywords: imipenem; pharmacodynamic analysis; analysis; model ... See more keywords
Aztreonam in combination with imipenem-relebactam against clinical and isogenic strains of serine and metallo-β-lactamase-producing enterobacterales.
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2022.115674
Abstract: OBJECTIVE The objective of this study was to evaluate the in vitro activity of aztreonam plus imipenem-relebactam against clinical and isogenic strains of Escherichia coli and Klebsiella pneumoniae co-harboring NDM and >1 serine β-lactamase. METHODS… read more here.
Keywords: relebactam clinical; combination; lactamase; imipenem relebactam ... See more keywords
Evaluating imipenem + cilastatin + relebactam for the treatment of complicated urinary tract infections
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1790525
Abstract: ABSTRACT Introduction The addition of the β-lactamase inhibitor relebactam to imipenem restores the antibacterial activity against the majority of multidrug resistant Gram-negative bacteria. Complicated urinary tract infections (UTIs) are predominantly caused by Gram-negative uropathogens. The… read more here.
Keywords: imipenem; relebactam; urinary tract; complicated urinary ... See more keywords
In vitro evaluation of double‐carbapenem combinations against OXA‐48‐producing Klebsiella pneumoniae isolates using time‐kill studies
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DOI: 10.1099/jmm.0.000725
Abstract: Purpose. The aim of this study was to evaluate the in vitro activity of double‐carbapenem combinations against OXA‐48‐producing Klebsiella pneumoniae clinical isolates. Methodology. Double combinations of ertapenem, meropenem and imipenem were evaluated for synergy and… read more here.
Keywords: imipenem; methodology; double carbapenem; carbapenem combinations ... See more keywords
In vitro activity of imipenem-relebactam against resistant phenotypes of Enterobacteriaceae and Pseudomonas aeruginosa isolated from intraabdominal and urinary tract infection samples - SMART Surveillance Europe 2015-2017.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001142
Abstract: Introduction. Infections attributable to carbapenem-resistant Gram-negative bacilli are increasing globally. New antimicrobial agents are urgently needed to treat patients with these infections.Aim. To describe susceptibility to the novel carbapenem-β-lactamase inhibitor combination imipenem-relebactam and comparators of… read more here.
Keywords: imipenem; relebactam; urinary tract; imipenem relebactam ... See more keywords
In Vitro Activity of Imipenem-Relebactam and Ceftolozane-Tazobactam against Resistant Gram-Negative Bacilli
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DOI: 10.1128/aac.00533-18
Abstract: Understanding which antimicrobial agents are likely to be active against Gram-negative bacilli can guide selection of antimicrobials for empirical therapy as mechanistic rapid diagnostics are adopted. In this study, we determined the MICs of a… read more here.
Keywords: imipenem; relebactam; negative bacilli; gram negative ... See more keywords
Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model
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DOI: 10.1128/aac.01764-20
Abstract: Combination therapy may enhance imipenem/cilastatin/relebactam’s (I/R) activity against Pseudomonas aeruginosa and suppress resistance development. Human-simulated unbound plasma concentrations of I/R at 1.25 g every 6 h (h), colistin at 360 mg daily, and amikacin at 25 mg/kg… read more here.
Keywords: combination; imipenem cilastatin; imipenem; cilastatin relebactam ... See more keywords
Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and Isogenic β-Lactam-Resistant Mutants
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DOI: 10.1128/aac.02165-19
Abstract: Imipenem and imipenem-relebactam MICs were determined for 1,445 Pseudomonas aeruginosa clinical isolates and a large panel of isogenic mutants showing the most relevant mutation-driven β-lactam resistance mechanisms. Imipenem-relebactam showed the highest susceptibility rate (97.3%), followed… read more here.
Keywords: clinical isolates; aeruginosa clinical; imipenem relebactam; imipenem ... See more keywords
IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae
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DOI: 10.1128/msphere.00736-19
Abstract: IMP-type metallo-β-lactamases comprise one group of the “Big 5” carbapenemases. Here, a novel blaIMP-68 gene encoding IMP-68 (harboring a Ser262Gly point mutant of IMP-11) was discovered from meropenem-resistant but imipenem-susceptible Klebsiella pneumoniae TA6363. The Ser262Gly… read more here.
Keywords: type metallo; susceptible klebsiella; imp type; imipenem ... See more keywords