Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2021.09.002
Abstract: Abstract In this research, a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine (MDSPE) and ethylene dimethacrylate (EDMA) to mimic bio-membrane environment. Excellent physicochemical properties of this novel monolith were achieved,… read more here.
Keywords: immobilized artificial; artificial membrane; phosphatidylethanolamine; biomimetic monolith ... See more keywords
Determination of in Vitro and in Silico Indexes for the Modeling of Blood-Brain Barrier Partitioning of Drugs via Micellar and Immobilized Artificial Membrane Liquid Chromatography.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01811
Abstract: In the present work, 79 structurally unrelated analytes were taken into account and their chromatographic retention coefficients, measured by immobilized artificial membrane liquid chromatography (IAM-LC) and by micellar liquid chromatography (MLC) employing sodium dodecyl sulfate… read more here.
Keywords: immobilized artificial; membrane liquid; liquid; artificial membrane ... See more keywords
Characterization of the Penetration of the Blood–Brain Barrier by High-Performance Liquid Chromatography (HPLC) Using a Stationary Phase with an Immobilized Artificial Membrane
Sign Up to like & getrecommendations! Published in 2018 at "Analytical Letters"
DOI: 10.1080/00032719.2018.1424175
Abstract: ABSTRACT The biological activity of drugs on organisms is associated with the pharmacokinetic properties, such as the ability to penetrate through environments of varying polarity such as cellular organelles. In this area, particular attention is… read more here.
Keywords: blood brain; immobilized artificial; artificial membrane; blood ... See more keywords
How can we better realize the potential of immobilized artificial membrane chromatography in drug discovery and development?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2020.1718101
Abstract: Biological membranes define boundaries between and within cells and organelles, which drugs have to cross in order to reach the various compartments where their receptors are located. For years, transport across membranes has been associated… read more here.
Keywords: chromatography; immobilized artificial; drug; drug discovery ... See more keywords
Affinity of Compounds for Phosphatydylcholine-Based Immobilized Artificial Membrane—A Measure of Their Bioconcentration in Aquatic Organisms
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12111130
Abstract: The BCF (bioconcentration factor) of solutes in aquatic organisms is an important parameter because many undesired chemicals enter the ecosystem and affect the wildlife. Chromatographic retention factor log kwIAM obtained from immobilized artificial membrane (IAM)… read more here.
Keywords: artificial membrane; immobilized artificial; bioconcentration; aquatic organisms ... See more keywords