Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
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DOI: 10.1021/acs.bioconjchem.7b00576
Abstract: The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was used… read more here.
Keywords: potency; cell killing; immolation; killing activity ... See more keywords
Suicide by self-immolation in southern Iran: an epidemiological study
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DOI: 10.1186/s12889-020-09778-z
Abstract: Self-immolation, as a method of suicide, is one of the most violent and extreme ways which is usually attempted by the ignition of inflammable materials, with more than 70% fatality rate. In the literature, Iran… read more here.
Keywords: self immolation; suicide self; study; immolation ... See more keywords
Challenges Facing Women Survivors of Self-Immolation in the Kurdish Regions of Iran: A Qualitative Study
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DOI: 10.3389/fpsyt.2020.00778
Abstract: Objectives Women confront many problems after self-immolation, so the purpose of this study was to explore the challenges facing women survivors of self-immolation in the Kurdish Regions of Iran. Method This study used a qualitative… read more here.
Keywords: self immolation; challenges facing; women survivors; study ... See more keywords
Self-Immolation among Women in Iran: A Narrative Review
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DOI: 10.5812/ijpbs.96557
Abstract: Context: Self-immolation is defined as ending life by suicide, particularly through burning, which carries considerable morbidity and mortality. Although its prevalence is low in developed countries, in developing countries, it’s an important problem. Evidence Acquisition:… read more here.
Keywords: self immolation; immolation among; among women; immolation ... See more keywords