Metformin and pancreatic cancer survival: Real effect or immortal time bias?
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32254
Abstract: High heterogeneity has been reported among cohort studies investigating the association between metformin and pancreatic cancer survival. Immortal time bias may be one importance source of heterogeneity, as it is widely present in previous cohort… read more here.
Keywords: cancer survival; time bias; pancreatic cancer; immortal time ... See more keywords
Simultaneously Dealing With Immortal Time Bias and Residual Confounding: A Case Study of a High‐Dimensional Propensity Score Approach With a Nested Case–Control Framework in Multiple Sclerosis Research
Sign Up to like & getrecommendations! Published in 2025 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.70174
Abstract: Observational studies of time‐dependent treatments often face immortal time bias and residual confounding, complicating treatment effect estimation. We implemented a high‐dimensional propensity score (hdPS) analysis within a nested case–control (NCC) framework to address both biases… read more here.
Keywords: time; time bias; immortal time; residual confounding ... See more keywords
Immortal time bias from selection: a principal stratification perspective.
Sign Up to like & getrecommendations! Published in 2025 at "American journal of epidemiology"
DOI: 10.1093/aje/kwaf146
Abstract: Immortal time bias due to post-treatment definition of eligibility criteria can affect experimental and observational studies, and yet, in contrast to the extensive literature on the classical form of immortal time bias, it has seldom… read more here.
Keywords: time; time bias; immortal time; principal stratification ... See more keywords
The effect of duration of therapy for treatment of Staphylococcus aureus blood stream infection: an application of cloning to deal with immortal-time bias in an analysis of data from a cohort study (BSI-FOO)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac374
Abstract: Abstract Objective To estimate the effect of treatment duration on in-hospital mortality in patients with Staphylococcus aureus blood stream infection and demonstrate the biases that can arise when immortal-time bias is ignored. Exposure We compared… read more here.
Keywords: immortal time; time bias; therapy; treatment ... See more keywords
Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology"
DOI: 10.1097/ede.0000000000001601
Abstract: Background: Randomized trials in pregnancy are extremely challenging, and observational studies are often the only option to evaluate medication safety during pregnancy. However, such studies are often susceptible to immortal time bias if treatment initiation… read more here.
Keywords: target trials; time; immortal time; time bias ... See more keywords
Letter by Cheen Regarding Article, "Outcomes Associated With Apixaban Use in Patients With End-Stage Kidney Disease and Atrial Fibrillation in the United States".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.118.038646
Abstract: March 19, 2019 1561 McVin Hua Heng Cheen, BSc (Pharm) (Hons), PhD To the Editor: I read with great interest the article by Siontis et al1 published in Circulation. As mentioned in the commentary, current… read more here.
Keywords: time; time bias; immortal time; apixaban ... See more keywords
Immortal time bias in the association between toxicity and response for immune checkpoint inhibitors: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15080
Abstract: e15080Background: A number of studies have addressed the association between Immune related Adverse Events (IrAE) and outcome in patients treated with Immune Checkpoint Inhibitors (ICI). Only a min... read more here.
Keywords: immune checkpoint; checkpoint inhibitors; association; time bias ... See more keywords