Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26477
Abstract: NOTCH1 belongs to the NOTCH family of proteins that regulate cell fate and inflammatory responses. Somatic and germline NOTCH1 variants have been implicated in cancer, Adams‐Oliver syndrome, and cardiovascular defects. We describe 7 unrelated patients… read more here.
Keywords: variants cause; cns immune; notch1 variants; heterozygous notch1 ... See more keywords
Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2133
Abstract: Schizophrenia is characterized by several core behavioral features, in which the gastrointestinal symptoms are frequently reported. Maternal immune activation (MIA) has been developed in a rodent model to study neurodevelopmental disorders such as schizophrenia. However,… read more here.
Keywords: immune activation; maternal immune; gut; alters adult ... See more keywords
Self‐Assembled Nano‐Immunostimulant for Synergistic Immune Activation
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700246
Abstract: Immunotherapy has become one of the most promising therapies for the treatment of diseases. Synthetic immunostimulants and nanomaterial immunostimulant systems are indispensable for the activation of the immune system in cancer immunotherapy. Herein, a strategy… read more here.
Keywords: immune; immune activation; synergistic immune; self assembled ... See more keywords
Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32008
Abstract: Hepatitis C virus (HCV) leads to a high rate of chronic infection and T cell dysfunction. Although it is well known that chronic antigenic stimulation is a driving force for impaired T cell functions, the… read more here.
Keywords: immune activation; cell; infection; hcv infection ... See more keywords
The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Experimental Analysis of Behavior"
DOI: 10.1002/jeab.753
Abstract: Rigorous behavioral analysis is essential to the translation of research conducted using animal models of neuropsychiatric disease. Here we discuss the use of operant paradigms within our lab as a powerful approach for exploring the… read more here.
Keywords: operant paradigms; model schizophrenia; maternal immune; research ... See more keywords
Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a1221-678rr
Abstract: Opioid use has negative effects on immune responses and may impair immune reconstitution in persons living with HIV (PLWH) infection undergoing antiretroviral treatment (ART). The effects of treatment with μ opioid receptor (MOR) agonists (e.g.,… read more here.
Keywords: immune reconstitution; inflammation; infection; use ... See more keywords
DNAzyme-Assisted Nano-Herb Delivery System for Multiple Tumor Immune Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202203942
Abstract: As a promising therapeutic strategy against cancer, immunotherapy faces critical challenges, especially in solid tumors. Immune checkpoint blockade therapy, particularly blocking the interaction of the programmed cell death 1 (PD1)-PD1 ligand 1 (PD-L1) axis, can… read more here.
Keywords: assisted nano; dnazyme assisted; tumor; activation ... See more keywords
Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205694
Abstract: Photodynamic therapy (PDT) can generate reactive oxygen species (ROS) to cause cell apoptosis and induce immunogenic cell death (ICD) to activate immune response, becoming a promising antitumor modality. However, the overexpressions of indoleamine 2,3-dioxygenase (IDO)… read more here.
Keywords: self delivery; tumor; photodynamic immunotherapy; immune activation ... See more keywords
Physical Activity and HIV: Effects on Fitness Status, Metabolism, Inflammation and Immune-Activation
Sign Up to like & getrecommendations! Published in 2019 at "AIDS and Behavior"
DOI: 10.1007/s10461-019-02510-y
Abstract: Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status,… read more here.
Keywords: status; immune activation; inflammation; physical activity ... See more keywords
Under the superficial dichotomy pathogen and allergen are two manifestations of same immune activation and pathogenesis mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2017.01.004
Abstract: Pathogens and allergens are deemed as two contrasting facets of host immune status, deficiency and exuberant. In silico domain analysis of a diverse panel of pathogen and allergen proteins has revealed the shortcoming of this… read more here.
Keywords: pathogen allergen; immune activation; pathogen; allergen ... See more keywords
Environmental influences on placental programming and offspring outcomes following maternal immune activation
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.08.192
Abstract: Adverse experiences during pregnancy induce placental programming, affecting the fetus and its developmental trajectory. However, the influence of 'positive' maternal experiences on the placenta and fetus remain unclear. In animal models of early life stress,… read more here.
Keywords: immune activation; maternal immune; mia; placental programming ... See more keywords