Mechanisms of immune aging in HIV.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20210344
Abstract: Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging.… read more here.
Keywords: hiv; infection; immune aging; hiv infection ... See more keywords
Assessing immune aging in HIV-infected patients
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DOI: 10.1080/21505594.2016.1195536
Abstract: ABSTRACT Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of… read more here.
Keywords: immune aging; assessing immune; infected patients; hiv infected ... See more keywords
Immunosenescence Inventory—a multi-omics database for immune aging research
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae1102
Abstract: Abstract The immune system is intricately interconnected with all other bodily systems. As individuals age, the immune system undergoes changes known as immunosenescence, increasing susceptibility to disease, and contributing significantly to the morbidity and mortality… read more here.
Keywords: immune aging; immunosenescence; immunosenescence inventory; research ... See more keywords
Abstract 1213: Immune aging impedes intratumoral T-cell activity to reduce response to therapy in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1213
Abstract: Age is the biggest risk factor for developing most cancers, including breast cancer. While over 50% of cancer cases occur in patients over 65, fewer than 25% of patients enrolled in clinical trials are in… read more here.
Keywords: age; cancer; breast cancer; immune aging ... See more keywords
Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma
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DOI: 10.1182/blood-2025-3952
Abstract: Smoldering Multiple Myeloma (SMM) is an asymptomatic plasma cell disorder with high risk of progression, characterized by clonal plasma cell expansion with no evidence of end-organ damage. In addition to tumor cells, evolving immune dysfunction… read more here.
Keywords: immune aging; disease; mif mediated; cell ... See more keywords