Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
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DOI: 10.1038/s41467-017-02251-3
Abstract: Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)−2 generate effective anti-tumor immunity but also elicit serious toxicities, hampering their clinical application. Here we show that combination therapy with anti-CD137 and an IL-2-Fc fusion achieves… read more here.
Keywords: immunity; anti cd137; toxicity; immune agonists ... See more keywords