Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13036
Abstract: Immune cells communicate by releasing large quantities of cytokines. Although the mechanisms of cytokine secretion are increasingly understood, quantitative knowledge of the number of cytokines per vesicle is still lacking. Here, we measured with quantitative… read more here.
Keywords: secretory vesicles; vesicles immune; contain limited; cells contain ... See more keywords
Pellino-2 in non-immune cells: novel interaction partners and intracellular localization.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14212
Abstract: Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in non-immune cells. Using yeast two-hybrid screening and co-immunoprecipitation,… read more here.
Keywords: interaction partners; pellino; novel interaction; immune cells ... See more keywords
Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.711
Abstract: Teriflunomide, a disease‐modifying treatment approved for multiple sclerosis (MS), inhibits reversibly dihydroorotate dehydrogenase, an enzyme involved in de novo pyrimidine biosynthesis and down‐regulates proliferation of activated lymphocytes. We aimed to study the impact of this… read more here.
Keywords: blood immune; tolerogenic bias; induces tolerogenic; immune cells ... See more keywords
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102581
Abstract: The tumor microenvironment (TME) is the environment around the tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM). Owing to its component interactions, the TME influences tumor growth and drug… read more here.
Keywords: tumor; cancer; immune cells; microenvironment ... See more keywords
Conscription of Immune Cells by Light‐Activatable Silencing NK‐Derived Exosome (LASNEO) for Synergetic Tumor Eradication
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DOI: 10.1002/advs.202201135
Abstract: Exosomes derived from natural killer (NK) cells (NEO) constitute promising antineoplastic nano‐biologics because of their versatile functions in immune regulation. However, a significant augment of their immunomodulatory capability is an essential need to achieve clinically… read more here.
Keywords: light activatable; silencing derived; activatable silencing; conscription immune ... See more keywords
Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation
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DOI: 10.1002/advs.202204335
Abstract: With the rapid growth of advanced nanoengineering strategies, there are great implications for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial to direct immunostimulators to the right tissue and specific immune cells… read more here.
Keywords: targeted cancer; clinical translation; immune cells; cancer ... See more keywords
Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor (Adv. Sci. 16/2022)
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DOI: 10.1002/advs.202270102
Abstract: Acoustofluidic Stimulation of Functional Immune Cells In article number 2105809, Jinsoo Park, Hyung Jin Sung, Jessie S. Jeon, and co‐workers employ surface acoustic waves to agitate fluid in a microreactor capable of dynamic cell culture… read more here.
Keywords: acoustofluidic stimulation; stimulation functional; stimulation; immune cells ... See more keywords
Neddylation‐CRLs regulate the functions of Treg immune cells
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DOI: 10.1002/bies.202200222
Abstract: Neddylation, a ubiquitylation‐like post‐translational modification, is catalyzed by a cascade composed of three enzymes: E1 activating enzyme, E2 conjugating enzyme, and E3 ligase with cullins as physiological substrates. Specifically, neddylation E2 UBE2M couples with E3… read more here.
Keywords: neddylation; regulate functions; neddylation crls; crls regulate ... See more keywords
Peripheral and tumor‐infiltrating immune cells are correlated with patient outcomes in ovarian cancer
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DOI: 10.1002/cam4.5590
Abstract: At present, there is still a lack of reliable biomarkers for ovarian cancer (OC) to guide prognosis prediction and accurately evaluate the dominant population of immunotherapy. In recent years, the relationship between peripheral blood markers… read more here.
Keywords: tumor infiltrating; ovarian cancer; peripheral tumor; immune cells ... See more keywords
Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells **
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DOI: 10.1002/cbic.202100521
Abstract: Current immunotherapeutics often work by directing components of the immune system to recognize biomarkers on the surface of cancer cells to generate an immune response. However, variable changes in biomarker distribution and expression can result… read more here.
Keywords: cancer cells; activates formyl; peptide receptor; formyl peptide ... See more keywords
Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints
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DOI: 10.1002/cbin.11955
Abstract: Pregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre‐eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In… read more here.
Keywords: treg cells; immune checkpoints; pregnancy; immune cells ... See more keywords