Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13036
Abstract: Immune cells communicate by releasing large quantities of cytokines. Although the mechanisms of cytokine secretion are increasingly understood, quantitative knowledge of the number of cytokines per vesicle is still lacking. Here, we measured with quantitative… read more here.
Keywords: secretory vesicles; vesicles immune; contain limited; cells contain ... See more keywords
Pellino-2 in non-immune cells: novel interaction partners and intracellular localization.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14212
Abstract: Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in non-immune cells. Using yeast two-hybrid screening and co-immunoprecipitation,… read more here.
Keywords: interaction partners; pellino; novel interaction; immune cells ... See more keywords
Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients
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DOI: 10.1002/acn3.711
Abstract: Teriflunomide, a disease‐modifying treatment approved for multiple sclerosis (MS), inhibits reversibly dihydroorotate dehydrogenase, an enzyme involved in de novo pyrimidine biosynthesis and down‐regulates proliferation of activated lymphocytes. We aimed to study the impact of this… read more here.
Keywords: blood immune; tolerogenic bias; induces tolerogenic; immune cells ... See more keywords
Vascularized lung cancer model for evaluating the promoted transport of anticancer drugs and immune cells in an engineered tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102581
Abstract: The tumor microenvironment (TME) is the environment around the tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM). Owing to its component interactions, the TME influences tumor growth and drug… read more here.
Keywords: tumor; cancer; immune cells; microenvironment ... See more keywords
Immunomodulatory Peptides for Tumor Treatment
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DOI: 10.1002/adhm.202400512
Abstract: Peptides exhibit various biological activities, including biorecognition, cell targeting, and tumor penetration, and can stimulate immune cells to elicit immune responses for tumor immunotherapy. Peptide self‐assemblies and peptide‐functionalized nanocarriers can reduce the effect of various… read more here.
Keywords: immune cells; peptides tumor; tumor immunotherapy; adaptive immune ... See more keywords
In Situ Reprogramming of Immune Cells Using Synthetic Nanomaterials
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DOI: 10.1002/adma.202310168
Abstract: In the past decade, adoptive cell therapy with chimeric antigen receptor‐T (CAR‐T) cells has revolutionized cancer treatment. However, the complexity and high costs involved in manufacturing current adoptive cell therapy greatly inhibit its widespread availability… read more here.
Keywords: cell therapy; immune cells; reprogramming immune; synthetic nanomaterials ... See more keywords
Reconciling the Cooperative–Competitive Patterns among Tumor and Immune Cells for Triple‐Negative Breast Cancer Treatment Using Multimodule Nanocomplexes
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DOI: 10.1002/adma.202312219
Abstract: Targeting the competitive–cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune‐dysfunction microenvironment to boost the immunotherapies for the triple‐negative breast cancer treatment. Hence, a bacterial outer membrane vesicle‐based nanocomplex is… read more here.
Keywords: breast cancer; immune cells; among tumor; negative breast ... See more keywords
Conscription of Immune Cells by Light‐Activatable Silencing NK‐Derived Exosome (LASNEO) for Synergetic Tumor Eradication
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DOI: 10.1002/advs.202201135
Abstract: Exosomes derived from natural killer (NK) cells (NEO) constitute promising antineoplastic nano‐biologics because of their versatile functions in immune regulation. However, a significant augment of their immunomodulatory capability is an essential need to achieve clinically… read more here.
Keywords: light activatable; silencing derived; activatable silencing; conscription immune ... See more keywords
Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation
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DOI: 10.1002/advs.202204335
Abstract: With the rapid growth of advanced nanoengineering strategies, there are great implications for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial to direct immunostimulators to the right tissue and specific immune cells… read more here.
Keywords: targeted cancer; clinical translation; immune cells; cancer ... See more keywords
Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor (Adv. Sci. 16/2022)
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DOI: 10.1002/advs.202270102
Abstract: Acoustofluidic Stimulation of Functional Immune Cells In article number 2105809, Jinsoo Park, Hyung Jin Sung, Jessie S. Jeon, and co‐workers employ surface acoustic waves to agitate fluid in a microreactor capable of dynamic cell culture… read more here.
Keywords: acoustofluidic stimulation; stimulation functional; stimulation; immune cells ... See more keywords
Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy
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DOI: 10.1002/advs.202416756
Abstract: Adjuvants, formulations, and processing of tumor antigens (collection, lysis, purification, and oxidation) can affect the therapeutic efficacy of cancer vaccines. To maximize their efficacy, adjuvants and their combinations are investigated to prepare vaccines with whole… read more here.
Keywords: cancer; immune cells; efficacy cancer; responders immunotherapy ... See more keywords