Immune-check blocking combination multiple cytokines shown curative potential in mice tumor model.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6053
Abstract: OBJECTIVE In order to ensure the stable transcription of target genes, we constructed a eukaryotic high expression vector carrying an immune-check inhibitor PD-1v and a variety of cytokines, and studied their effects on activating immune… read more here.
Keywords: mice tumor; tumor growth; combination; tumor ... See more keywords
Immune check-point in endometrial cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01437-7
Abstract: BackgroundEndometrial cancer (EC) is one of the most frequent tumors in women. Despite recent advances in treatment approaches, the prognosis in advanced, recurrent, or metastatic disease remains poor. The aim was to provide the clinician… read more here.
Keywords: immune check; point inhibitors; check point; point ... See more keywords
Expected Paradigm Shift in Brain Metastases Therapy—Immune Checkpoint Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0905-3
Abstract: Brain metastasis (BM) is one of the dreadful complications of malignancies. The prognosis after BM is extremely poor and life expectancy is meager. Currently, our treatment modalities are limited to radiotherapy and surgical resection, which… read more here.
Keywords: immune checkpoint; immune check; checkpoint inhibitors; check point ... See more keywords
Targeting immune checkpoints in non small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2018.02.006
Abstract: HighlightsOncogenic drivers and mechanisms of adaptive immunity are changing the landscape of lung cancer treatment.Cancers can disrupt cancer cell immune recognition by interfering with immune‐check‐point pathways.Immune check point molecules PD‐1, PD‐L1 and CTLA‐4 are relevant… read more here.
Keywords: immune check; lung cancer; non small; cancer ... See more keywords
Immune check-point in glioblastoma multiforme.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.03.019
Abstract: Glioblastoma multiforme (GBM) represents one of the main frequent and aggressive primary brain neoplasms among adults worldwide. Despite a first-line multimodal treatment, including radical surgery and adjuvant radiation therapy with concomitant temozolomide-based chemotherapy, GBM prognosis… read more here.
Keywords: check point; immune check; glioblastoma multiforme;
Dual immune check point blockade or immune check point-tyrosine kinase inhibitor combination: as a first-line treatment in metastatic renal cell carcinoma?
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000000874
Abstract: Purpose of review To discuss treatment decisions in the first-line setting of metastatic renal cell carcinoma (mRCC). Recent findings Immune check point inhibitor (ICI) combinations have replaced sunitinib as the standard of care in the… read more here.
Keywords: treatment; check point; immune check; first line ... See more keywords
Immune check‐point inhibitor‐related pneumonitis: acute lung injury with rapid progression and organising pneumonia with less severe clinical disease
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14704
Abstract: To improve understanding of the pathology of immune check‐point inhibitor (ICI)‐related pneumonitis, clinical, radiographic and histopathological features and outcomes were investigated in a cohort of patients who were treatment‐naive before receiving ICI inhibition, who underwent… read more here.
Keywords: related pneumonitis; lung injury; check point; point inhibitor ... See more keywords
Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono?
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DOI: 10.1136/gutjnl-2022-327132
Abstract: Data from the United States, Surveillance, Epidemiology, and End Results Program reveal that hepatocellular carcinoma (HCC) 5- year relative survival is 20.3% livibd.html). ‘Approximately, 1.0% of men and women will be diagnosed with liver and… read more here.
Keywords: hepatocellular carcinoma; check point; point inhibitors; immune check ... See more keywords
Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2022.37.e338
Abstract: Background Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy. To define the altered pathway in GDM placenta, we investigated the transcriptomic profiles from human placenta between GDM and controls. Methods Clinical… read more here.
Keywords: gestational diabetes; senescent cells; cells immune; diabetes mellitus ... See more keywords
Immune Check Point Inhibitors and Immune-Related Adverse Events in Small Cell Lung Cancer
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DOI: 10.3389/fonc.2021.604227
Abstract: Small cell lung cancer (SCLC) is a malignant solid tumor. In recent years, although immune check point inhibitors (ICIs) have achieved important advances in the treatment of SCLC, immune-related adverse events (irAEs) have occurred at… read more here.
Keywords: immune check; point inhibitors; check point; cell lung ... See more keywords
Crosstalk between ILC3s and Microbiota: Implications for Colon Cancer Development and Treatment with Immune Check Point Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15112893
Abstract: Simple Summary In recent years, growing evidence has suggested that the gut microbiome can significantly influence antitumor immunity, both within and outside the gastrointestinal tract, thereby affecting the efficacy of immune checkpoint inhibitors (ICIs. A… read more here.
Keywords: microbiota; check point; colon cancer; immune check ... See more keywords