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Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.0354
Abstract: Importance De novo bullous pemphigoid (BP) is a rare immune-mediated adverse event from immune checkpoint inhibitors (ICIs) that can necessitate permanent discontinuation of the anticancer therapy, but the risk factors for developing this toxic effect… read more here.
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Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.6803
Abstract: Key Points Question How frequently do immune checkpoint inhibitor (ICI) agents vs non-ICI agents qualify for American Society of Clinical Oncology Value Framework version 2 (ASCO-VF v2) tail-of-the-curve bonuses or European Society of Medical Oncology… read more here.
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Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.1611
Abstract: This systematic review and meta-analysis evaluates the immune checkpoint inhibitor regimens used along with the incidence of adverse events reported in randomized clinical trials for treatment of advanced melanoma. read more here.
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Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.28627
Abstract: Key Points Question When compared with prior therapies, are immune checkpoint inhibitors for metastatic melanoma associated with development of second primary cancers? Findings In this cohort study of 5016 patients with metastatic melanoma between 2005… read more here.
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Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.26252
Abstract: This systematic review and meta-analysis of randomized clinical trials involving patients with solid tumors assesses the association of immune checkpoint inhibitors with patient-reported quality of life. read more here.
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Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.27211
Abstract: Key Points Question Is there a difference in survival outcomes associated with immune checkpoint inhibitor therapy compared with chemotherapy when corrected for error introduced by Cox proportional hazards analysis? Findings In this systematic review and… read more here.
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Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.28452
Abstract: This cross-sectional study examines whether patients with cancer without symptoms of immune checkpoint inhibitor toxic effects can be accurately identified using a text message–based triage instrument and safely proceed to treatment. read more here.
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Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.52244
Abstract: This comparative effectiveness research study compares outcomes of first-line therapy with immune checkpoint inhibitors vs chemotherapy among patients who have metastatic colorectal cancer with high microsatellite instability, mismatch repair deficiency, and/or high tumor mutational burden. read more here.
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Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.7444
Abstract: This cohort study uses published clinical trial data to assess long-term survival of patients with metastatic urothelial carcinoma who are treated with immune checkpoint inhibitors. read more here.
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Published in 2021 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2021.0249
Abstract: Importance Encephalitis is a severe immune-related adverse event secondary to treatment with immune checkpoint inhibitors (ICIs). The spectrum of ICI-induced encephalitis (ICI-iE) ranges from disease that resolves fully to lethal forms. Moreover, ICIs may unmask… read more here.
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Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3462
Abstract: Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma The management of advanced melanoma has witnessed dramatic changes in recent years with the rational development of novel… read more here.