Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12394
Abstract: Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell adoptive immunotherapy in humans has shown modest efficacy. In… read more here.
Keywords: natural killer; killer cells; immune checkpoints; solid tumors ... See more keywords
Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11955
Abstract: Pregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre‐eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In… read more here.
Keywords: treg cells; immune checkpoints; pregnancy; immune cells ... See more keywords
The role of ubiquitin pathway‐mediated regulation of immune checkpoints in cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34729
Abstract: With the continuous cognition of the relationship between tumor cells and tumor immune microenvironment, immunotherapy based on the immune checkpoint blockade has achieved great breakthroughs, led to improved clinical outcomes, and prolonged survival for cancer… read more here.
Keywords: immunotherapy; immune checkpoints; regulation; tumor ... See more keywords
A comprehensive profiling of soluble immune checkpoints from the sera of patients with non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24224
Abstract: Immunotherapy was widely used for the treatment of non‐small cell lung cancer (NSCLC). However, whether inhibition of immune checkpoints individually or simultaneously could improve the therapeutic efficacy of NSCLC remains to be investigated. Here, we… read more here.
Keywords: lung cancer; non small; small cell; immune checkpoints ... See more keywords
Bone marrow free immune checkpoints as a potential biomarker for differential diagnosis of acquired bone marrow failures
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24677
Abstract: Clinically, to make a definite diagnosis of aplastic anemia (AA), idiopathic cytopenia of undetermined significance (ICUS) or myelodysplastic syndrome (MDS), they should be distinguished from each other. AA and ICUS have some incidence to transform… read more here.
Keywords: mds; bone marrow; marrow; diagnosis ... See more keywords
Immune checkpoints in hematologic malignancies: What made the immune cells and clinicians exhausted!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29769
Abstract: Hematologic malignancies comprise a considerable part of cancers with high mortality at any age. Since the introduction of hematopoietic stem cell transplantation (HSCT), the overall survival of patients dramatically increased. The main goal of HSCT… read more here.
Keywords: hematologic malignancies; physiology; checkpoints hematologic; immune cells ... See more keywords
Immune checkpoints in T cells during oncogenic γ‐herpesvirus infections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27840
Abstract: Epstein–Barr virus (EBV) and Kaposi sarcoma‐associated herpesvirus (KSHV) are two persistent oncogenic γ‐herpesviruses with an exclusive tropism for humans. They cause cancers of lymphocyte, epithelial and endothelial cell origin, such as Burkitt's and Hodgkin's lymphoma,… read more here.
Keywords: checkpoints cells; immune checkpoints; ebv kshv; cells oncogenic ... See more keywords
Structures of Immune Checkpoints: An Overview on the CD28-B7 Family.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_3
Abstract: The co-stimulation and co-inhibition signal pathways, immune checkpoints, are among the central mechanisms to regulate the T-cell immunity. Optimal signals involve intricate interactions of numerous ligands and receptors. Manipulation of these signals offers great clinical… read more here.
Keywords: medicine; structures immune; cancer; immune checkpoints ... See more keywords
Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02978-5
Abstract: AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired… read more here.
Keywords: dysfunctional phenotype; aml patients; expressing cells; increased tigit ... See more keywords
Targeting Immune Checkpoints in Lung Cancer: Current Landscape and Future Prospects
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DOI: 10.1007/s40261-018-00746-5
Abstract: Lung cancer is the most prevalent and deadly cancer worldwide. Immune checkpoint therapy, which targets regulatory pathways in T cells to boost anti-tumor immune response, has revolutionized lung cancer treatment paradigms. Inhibitors of the most established immune… read more here.
Keywords: cancer; immune checkpoint; immune checkpoints; lung cancer ... See more keywords
From immune checkpoints to vaccines: The past, present and future of cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2019.03.002
Abstract: Cancer is a worldwide medical problem with significant repercussions on individual patients and societies as a whole. In order to alter the outcomes of this deadly disease the treatment of cancer over the centuries has… read more here.
Keywords: immune checkpoints; immunotherapy; immune system; cancer ... See more keywords