Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti‐HpTGEKP Antibody and Zinc Finger Protein Linker Phospho‐Hexapeptides
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DOI: 10.1002/cbic.202200390
Abstract: Accurate formation of antibody‐antigen complexes has been relied on in both, multitudes of scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically determined dissociation behavior of immune complexes with the anti‐HpTGEKP antibody revealed that… read more here.
Keywords: immune complexes; linker; phospho; zinc finger ... See more keywords
A novel general and efficient technique for dissociating antigen in circulating immune complexes
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700246
Abstract: Circulating immune complexes (CICs) are produced during the immune response. It is more clinically important to establish a general and efficient CICs dissociation technique for the detection of antigens for CICs other than the detection… read more here.
Keywords: technique; immune complexes; dissociation; precipitation ... See more keywords
Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis
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DOI: 10.1007/s12026-018-9052-1
Abstract: Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data… read more here.
Keywords: immune complexes; pulmonary tuberculosis; complexes patients; etiology ... See more keywords
Making Weak Antigens Strong: Preparing Immune Complexes for Injection.
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DOI: 10.1101/pdb.prot099978
Abstract: If antibodies against a particular antigen are available, that antigen can be purified and used for further immunizations, and antigens thus purified can show enhanced immunogenicity. Purified immune complexes can be injected directly, or while… read more here.
Keywords: immune complexes; strong preparing; antigens strong; weak antigens ... See more keywords
Identification and characterization of circulating immune complexes in IgA nephropathy
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DOI: 10.1126/sciadv.abm8783
Abstract: The underlying pathology of immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is driven by the deposition of immune complexes containing galactose-deficient IgA1 [Tn(+)IgA1] in the glomerular mesangium. Here, we report that novel… read more here.
Keywords: circulating immune; iga nephropathy; characterization circulating; immune complexes ... See more keywords
A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab
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DOI: 10.1126/scitranslmed.abq5068
Abstract: Immunogenicity against intravitreally administered brolucizumab has been previously described and associated with cases of severe intraocular inflammation, including retinal vasculitis/retinal vascular occlusion (RV/RO). The presence of antidrug antibodies (ADAs) in these patients led to the… read more here.
Keywords: pharmacology; immune complexes; immunogenicity; mechanistic drivers ... See more keywords
Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes.
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DOI: 10.1182/blood.2020009487
Abstract: Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies to a multivalent antigen composed of platelet factor 4 (PF4) and heparin. The limitations of current anti-thrombotic therapy in… read more here.
Keywords: immune; immune complexes; complement mediates; ultra large ... See more keywords
Paraffin immunofluorescence for detection of immune complexes in renal biopsies: an efficient salvage technique for diagnosis of glomerulonephritis in dogs
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DOI: 10.1186/s12917-017-1287-x
Abstract: BackgroundRenal biopsy is an essential tool for the diagnosis of proteinuric kidney diseases in dogs, and evaluation of immune complexes (IC) by immunofluorescence (IF) of frozen sections (IF-F) is required for the diagnosis of IC-mediated… read more here.
Keywords: immune complexes; technique diagnosis; diagnosis; immunofluorescence ... See more keywords
Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion
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DOI: 10.12688/f1000research.14406.1
Abstract: Background: Large protein aggregates, known as circulating immune complexes (CICs), are formed in biological fluids as a result of the development of the body's immune response to various provoking factors. The kinetic characteristics of the… read more here.
Keywords: immune complexes; isotypic composition; removal; process digestion ... See more keywords
Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes
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DOI: 10.1371/journal.pone.0170556
Abstract: A paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against IgG in various physical… read more here.
Keywords: immune complexes; mab; isogenic igg; immunogenicity isogenic ... See more keywords
Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes
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DOI: 10.1371/journal.pone.0198609
Abstract: Macrophages exhibit diverse effector phenotypes depending on the stimuli and their microenvironment. Classically activated macrophages are primed with interferon (IFN)γ and stimulated with pathogen-associated molecular patterns. They produce inflammatory mediators and inflammatory cytokines, such as… read more here.
Keywords: immune complexes; notch signaling; stimulated macrophages; presence immune ... See more keywords