Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57297-5
Abstract: Harnessing the power of immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry by genomic alterations enables tumor cells to escape immune surveillance, leading to therapeutic failure. Uncovering… read more here.
Keywords: cancer; immune dependent; lung cancer; lkb1 ... See more keywords
Local anesthetics elicit immune-dependent anticancer effects
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DOI: 10.1136/jitc-2021-004151
Abstract: Background Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery. Here, we investigated the anticancer effects of six local anesthetics used… read more here.
Keywords: stress; local anesthetics; immune dependent; anticancer effects ... See more keywords
Abstract 3419: EPS 226, a novel HER2 targeting IgE therapeutic, delivers immune dependent anti-tumor activity in preclinical models of breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3419
Abstract: HER2 is expressed at low levels in approximately 30-40% of cancers, including in breast cancer patients. Therapeutic IgE antibodies have been shown to deliver robust immune-dependent preclinical anti-tumor activity across a wide range of antigen… read more here.
Keywords: breast cancer; immune dependent; eps 226; her2 ... See more keywords