Studies of Isolated Peripheral Blood Cells as a Model of Immune Dysfunction.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7614-0_12
Abstract: Peripheral blood mononuclear cells (PBMCs) have been used as a surrogate model of immune function in studies of multiple medical areas, such as metabolic diseases and immune dysfunction. This chapter describes a standardized technique for… read more here.
Keywords: model immune; immune dysfunction; peripheral blood; blood ... See more keywords
Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies
Sign Up to like & getrecommendations! Published in 2017 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-017-0410-1
Abstract: Purpose of this ReviewThe present review focuses on key aspects of non-Hodgkin lymphoma (NHL) evasion of immune surveillance and how these can be leveraged to devise effective immunotherapy strategies.Recent FindingsIn recent years, significant progress has… read more here.
Keywords: hodgkin lymphoma; non hodgkin; immune dysfunction; immunotherapy ... See more keywords
Toll‐like receptor 4 deficiency increases resistance in sepsis‐induced immune dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.11.006
Abstract: ABSTRACT Sepsis constitutes a serious life‐threatening syndrome associated with complications of deregulated inflammatory response against endotoxin/lipopolysaccharide (LPS)‐mediated severe infection. Toll‐like receptor 4 (TLR4) plays a critical role in the activation of innate immunity through recognition… read more here.
Keywords: sepsis; immune dysfunction; tlr4; activity ... See more keywords
Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2021.110647
Abstract: Chronic fatigue and Immune Dysfunction Syndrome (CFIDS) is a heterogeneous disease that may be promoted by various environmental stressors, including viral infection, toxin uptake, and ionizing radiation exposure. Previous studies have identified mitochondrial dysfunction in… read more here.
Keywords: radiation exposure; dysfunction; immune dysfunction; chronic fatigue ... See more keywords
Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0948-x
Abstract: Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the… read more here.
Keywords: inflammation immune; anticancer drugs; immune dysfunction; dysfunction coagulopathy ... See more keywords
Unmasking Unique Immune Altering Aspects of the Microbiome as a Tool to Correct Sepsis-Induced Immune Dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Surgical infections"
DOI: 10.1089/sur.2020.233
Abstract: Background: Sepsis-related mortality is driven by immune dysfunction. A bidirectional micro-organism-immune cell cross talks exists. Gut Bacteroides fragilis-T-cell crosstalk maintains innate immune cell/pathogen homeostasis. Commensal gut Clostridia spp. suppress inflammation and induce gut tolerance. Probiotics… read more here.
Keywords: sepsis; immune dysfunction; bacteroides fragilis; induced immune ... See more keywords
Liver cirrhosis and immune dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac030
Abstract: Cirrhosis is end-stage liver disease resulting from various etiologies and is a common cause of death worldwide. The progression from compensated to decompensated cirrhosis to acute-on-chronic liver failure (ACLF) is due to multiple factors, including… read more here.
Keywords: liver cirrhosis; liver; cirrhosis; immune dysfunction ... See more keywords
The aging transplant population and immunobiology: any therapeutic implication?
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000760
Abstract: PURPOSE OF REVIEW The aim of this review is to describe the latest investigations into the immunobiology of aging and the potential impact on outcomes after mechanical circulatory support implantation and heart transplantation. This information… read more here.
Keywords: heart; population; aging transplant; immune dysfunction ... See more keywords
Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001748
Abstract: BACKGROUND Exosomes are extracellular vesicles that act as endogenous mediators of the immune response. We have previously shown that exosomes released into mesenteric lymph (ML) following trauma (T)/hemorrhagic shock (HS) induce proinflammatory cytokine production in… read more here.
Keywords: epithelial cell; dysfunction; posttrauma immune; immune dysfunction ... See more keywords
Immune Dysfunction in Patients with Chronic Lymphocytic Leukemia and Challenges during COVID-19 Pandemic
Sign Up to like & getrecommendations! Published in 2021 at "Acta Haematologica"
DOI: 10.1159/000514071
Abstract: The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been first described in December 2019 in Wuhan, China, and has led to a worldwide pandemic ever since. Initial clinical data imply that cancer patients are… read more here.
Keywords: lymphocytic leukemia; immune dysfunction; patients chronic; chronic lymphocytic ... See more keywords
Eosinophils and eosinophilic immune dysfunction in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "European Respiratory Review"
DOI: 10.1183/16000617.0150-2021
Abstract: The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood… read more here.
Keywords: health; disease; eosinophils eosinophilic; eosinophilic immune ... See more keywords