Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25365
Abstract: Peripheral blood biomarkers of tumor microenvironment and immune surveillance are independent prognostic factors in multiple myeloma. The timing and prognostic impact of immune reconstitution has been studied after autologous hematopoietic stem cell transplantation, less is… read more here.
Keywords: early immune; newly diagnosed; reconstitution; multiple myeloma ... See more keywords
Towards gene therapy for IPEX syndrome
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DOI: 10.1002/eji.202149210
Abstract: Immune dysregulation polyendocrinopathy enteropathy X linked (IPEX) syndrome is an uncurable disease of the immune system, with immune dysregulation that is caused by mutations in FOXP3. Current treatment options, such as pharmacological immune suppression and… read more here.
Keywords: ipex syndrome; gene; gene therapy; immune dysregulation ... See more keywords
Immune‐dysregulation in subacute sclerosing panencephalitis: An exploratory case–control study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28504
Abstract: Subacute sclerosing panencephalitis (SSPE) is a chronic progressive neurological condition caused by a defective measles virus. It is postulated that immune‐dysregulation might result in persistent infection (immune evasion) as well as initiation of autoimmune phenomenon… read more here.
Keywords: panencephalitis; control study; immune dysregulation; dysregulation ... See more keywords
Pulmonary manifestations of immune dysregulation in CTLA‐4 haploinsufficiency and LRBA deficiency
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DOI: 10.1002/ppul.25373
Abstract: The primary immunodeficiency syndromes of cytotoxic T lymphocyte‐associated protein 4 (CTLA‐4) haploinsufficiency and lipopolysaccharide‐responsive and beige‐like anchor protein (LRBA) deficiency present with multisystem immune dysregulation. The aim of this study was to characterize and compare… read more here.
Keywords: ctla haploinsufficiency; pulmonary manifestations; immune dysregulation; lrba deficiency ... See more keywords
Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25924
Abstract: In recent years, a growing number of monogenic disorders have been described that are characterized by immune dysregulation. A subset of these “primary immune regulatory disorders” can cause severe interstitial lung disease, often recognized in… read more here.
Keywords: disease; immune dysregulation; genetic diagnosis; lung disease ... See more keywords
Immune dysregulation and RNA N6‐methyladenosine modification in sepsis
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DOI: 10.1002/wrna.1764
Abstract: Sepsis is defined as life‐threatening organ dysfunction caused by the host immune dysregulation to infection. It is a highly heterogeneous syndrome with complex pathophysiological mechanisms. The host immune response to sepsis can be divided into… read more here.
Keywords: sepsis; modification; rna methyladenosine; modification sepsis ... See more keywords
Altered Spectrum of Lymphoid Neoplasms in a Single-Center Cohort of Common Variable Immunodeficiency with Immune Dysregulation
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DOI: 10.1007/s10875-021-01016-4
Abstract: Purpose Common variable immune deficiency (CVID) confers an increased risk of lymphoid neoplasms, but reports describing the precise WHO specification of the lymphoma subtypes and their immunological environment are lacking. We therefore classified lymphomas—occurring in… read more here.
Keywords: lymphoma; lymphoid neoplasms; common variable; cohort ... See more keywords
Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders
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DOI: 10.1007/s11920-018-0945-4
Abstract: Purpose of ReviewWhile genetic factors are a major etiological contributor to autism spectrum disorder (ASD), evidence also supports a role for environmental factors. Herein, we will discuss two such factors that have been associated with… read more here.
Keywords: prenatal stress; maternal immune; immune dysregulation; autism spectrum ... See more keywords
Autoantibodies in immunodeficiency syndromes: The Janus faces of immune dysregulation.
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DOI: 10.1016/j.blre.2022.100948
Abstract: Immunodeficiency syndromes represent a diverse group of inherited and acquired disorders, characterized by a spectrum of clinical manifestations, including recurrent infections, autoimmunity, lymphoproliferation and malignancy. Autoantibodies against various self-antigens reflect the immune dysregulation underlying these… read more here.
Keywords: janus faces; immune dysregulation; syndromes janus; immunodeficiency syndromes ... See more keywords
Immune Dysregulation in the Pathogenesis of Atopic Dermatitis
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DOI: 10.1097/der.0000000000000340
Abstract: Atopic dermatitis is a multifactorial disease. Epidermal barrier impairment often plays the initial role in the initiation of the disease. Immune dysregulation of the innate and adaptive immunity plays a central role in the pathogenesis… read more here.
Keywords: atopic dermatitis; dermatitis; pathogenesis atopic; immune dysregulation ... See more keywords
The phenotypical implications of immune dysregulation in fragile X syndrome
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DOI: 10.1111/ene.14146
Abstract: Immune system dysfunction and inflammatory dysregulation have been shown in several animal models of fragile X syndrome (FXS). However, the phenotypical implications of this dysregulation have not been systematically evaluated in a large patient cohort. read more here.
Keywords: dysregulation fragile; fragile syndrome; dysregulation; phenotypical implications ... See more keywords