Managing Treatment‐Emergent Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CAR‐T Cell Therapy: A Case‐Based Review of the use of Emapalumab
Sign Up to like & getrecommendations! Published in 2025 at "Hematological Oncology"
DOI: 10.1002/hon.70157
Abstract: ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapies have revolutionized the treatment of hematological malignancies, achieving high response rates in patients with relapsed or refractory disease. Despite these benefits, CAR‐T cell therapies are associated with… read more here.
Keywords: immune effector; therapy; car cell; cell associated ... See more keywords
Expression of IgG Monoclonals with Engineered Immune Effector Functions.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8648-4_16
Abstract: The therapeutic development of monoclonal antibodies requires robust and reliable methods for their recombinant expression and characterization. In this context, an increasingly important aspect in the antibody development process is to determine the contribution of… read more here.
Keywords: expression igg; effector functions; immune effector; monoclonals engineered ... See more keywords
Implementing Immune Effector Cell Education for Nursing Staff
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.476
Abstract: Topic Significance & Study Purpose/Background/Rationale Immune effector cell therapy (IECT) has recently emerged as a revolutionary treatment approach for several hematologic malignancies but is associated with unique administration and management considerations. With the growing number… read more here.
Keywords: cancer; education; immune effector; class ... See more keywords
Immune Effector Cell Associated Neurotoxicity (ICANS) Among Pediatric and AYA Patients: MD Anderson Cancer Center Experience
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.397
Abstract: Introduction Immune effector cell associated neurotoxicity (ICANS) and cytokine release syndrome (CRS) are unique potentially life-threatening complications associated with immune effector cell (IEC) therapies. ICANS presents with varying symptoms ranging from confusion to seizure and… read more here.
Keywords: cell; aya patients; pediatric aya; immune effector ... See more keywords
Targeted recruitment of immune effector cells for rapid eradication of influenza virus infections
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2408469121
Abstract: Significance Concerns over periodic influenza pandemics remain high, primarily because current therapies are ineffective in treating advanced stages of disease and generally less effective in treating avian influenza virus strains against which we have little… read more here.
Keywords: recruitment immune; immune effector; virus; targeted recruitment ... See more keywords
Multifocal demyelinating leukoencephalopathy and oligodendroglial lineage cell loss with immune effector cell-associated neurotoxicity syndrome (ICANS) following CD19 CAR T-cell therapy for mantle cell lymphoma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac121
Abstract: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a prevalent condition seen after treatment with chimeric antigen receptor T-cell (CAR T) therapy and other cancer cell therapies. The underlying pathophysiology and neuropathology of the clinical syndrome… read more here.
Keywords: cell; cell associated; therapy; car ... See more keywords
Use of Dasatinib for the Treatment of Refractory Immune Effector Cell‐Associated Neurotoxicity Syndrome After Axicabtagene Ciloleucel Infusion: A Case Report
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Haematology"
DOI: 10.1111/ejh.70038
Abstract: Chimeric antigen receptor (CAR) T‐cell therapy is a well‐established approach for refractory hematological malignancies. Cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) remain a major concern of CAR T‐cell therapy, particularly in… read more here.
Keywords: treatment; immune effector; refractory; cell associated ... See more keywords
Immune effector mechanisms in malaria: An update focusing on human immunity
Sign Up to like & getrecommendations! Published in 2019 at "Parasite Immunology"
DOI: 10.1111/pim.12628
Abstract: The past decade has witnessed dramatic decreases in malaria‐associated mortality and morbidity around the world. This progress has largely been due to intensified malaria control measures, implementation of rapid diagnostics and establishing a network to… read more here.
Keywords: malaria update; immunity; mechanisms malaria; immune effector ... See more keywords
Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Sign Up to like & getrecommendations! Published in 2024 at "Blood Advances"
DOI: 10.1182/bloodadvances.2024014455
Abstract: Key Points • Disease type, baseline cytopenia, lymphodepletion intensity, and systemic inflammation were strongly associated with severe eICAHT.• We validated 2 prediction models of grade 3 to 4 ICAHT with near-perfect calibration, high discrimination, and… read more here.
Keywords: early immune; immune effector; predictive models; models early ... See more keywords
Impact of the body mass index on perioperative immunological disturbances in patients with hip and knee arthroplasty
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-017-0557-4
Abstract: BackgroundObesity increases the risk for knee and hip joint implantation and negatively contributes to wound healing. In this study, in 52 patients undergoing hip and knee arthroplasty the amount of peripheral immune effector cells pre-… read more here.
Keywords: peripheral cells; bmi; immune effector; knee arthroplasty ... See more keywords
A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00369
Abstract: The gut microbiome of animals consists of diverse microorganisms that include both prokaryotes and eukaryotes. Complex interactions occur among these inhabitants, as well as with the immune system of the host, and profoundly influence the… read more here.
Keywords: binds fungi; fungi bacteria; immune effector; soluble immune ... See more keywords