Prognostic role of immune environment in luminal B early breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5642
Abstract: The importance of the immune microenvironment in triple negative and HER2‐amplified breast cancer (BC) is well‐established; less is known about the immune environment in luminal breast cancers. We aimed to assess for the impact of… read more here.
Keywords: early breast; breast; breast cancer; immune environment ... See more keywords
Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104864
Abstract: The prenatal environment, and in particular, the maternal-fetal immune environment, has emerged as a targeted area of research for central nervous system (CNS) diseases with neurodevelopmental origins. Converging evidence from both clinical and preclinical research… read more here.
Keywords: mia model; immune activation; maternal immune; immune environment ... See more keywords
The Interplay between RNA Editing Regulator ADAR1 and Immune Environment in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/9315027
Abstract: An abnormality in the regulation of adenosine deaminase acting on RNA (ADAR) enzymes, which catalyzed adenosine-to-inosine (A-to-I) RNA editing, was closely associated with the highly aggressive biologic behavior and poor prognosis in many malignancies. In… read more here.
Keywords: rna editing; adar; immune environment; adar mrna ... See more keywords
Responses of regulatory and effector T-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.891925
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT). Tregs promptly respond to low concentrations of IL-2 through the constitutive expression of… read more here.
Keywords: cell; environment; transplantation; immune environment ... See more keywords
CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.991797
Abstract: Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of skin cancer. SKCM is characterized by high lymphocytic infiltration, whereas the states of infiltrated cells are variable… read more here.
Keywords: prognosis; tumor immune; immune environment; tumor ... See more keywords
Explant Modeling of the Immune Environment of Head and Neck Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.611365
Abstract: Patients exhibit distinct responses to immunotherapies that are thought to be linked to their tumor immune environment. However, wide variations in outcomes are also observed in patients with matched baseline tumor environments, indicating that the… read more here.
Keywords: response; treatment; immune environment; environment ... See more keywords
Importance of the endometrial immune environment in endometrial cancer and associated therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.975201
Abstract: Endometrial cancer is rising in prevalence. The standard treatment modality of hysterectomy is becoming increasingly inadequate due primarily to the direct link between endometrial cancer and high BMI which increases surgical risks. This is an… read more here.
Keywords: endometrial cancer; immune environment; importance endometrial; cancer ... See more keywords
Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors
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DOI: 10.3390/cancers15072042
Abstract: Simple Summary Endometrial (EC) and cervical cancers (CC) do not respond well to chemotherapy and alternative therapeutic options are lacking. Recently, EC and CC patients’ outcome were improved thanks to immunotherapy-based treatments leading to their… read more here.
Keywords: immunotherapy; immunotherapy endometrial; environment immunotherapy; immune environment ... See more keywords
Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models
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DOI: 10.7554/elife.85739
Abstract: The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immune evasion in mouse models… read more here.
Keywords: breast cancer; immune environment; secretion; kindlin ... See more keywords