Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202937
Abstract: Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its… read more here.
Keywords: setd2 deficiency; immune escape; escape pancreatic; pancreatic tumorigenesis ... See more keywords
The global epidemic of SARS-CoV-2 variants and their mutational immune escape.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27376
Abstract: During the COVID-19 pandemic, genetic variants of SARS-CoV-2 have been emerging and spreading around the world. Several SARS-CoV-2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and Apr-2021. Studies… read more here.
Keywords: epidemic sars; global epidemic; cov variants; immune escape ... See more keywords
The outbreak of SARS‐CoV‐2 Omicron lineages, immune escape, and vaccine effectivity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28138
Abstract: As of November 2021, several SARS‐CoV‐2 variants appeared and became dominant epidemic strains in many countries, including five variants of concern (VOCs) Alpha, Beta, Gamma, Delta, and Omicron defined by the World Health Organization during… read more here.
Keywords: omicron; immune escape; omicron lineages; outbreak sars ... See more keywords
Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28519
Abstract: Genetic recombination is an important driver of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) evolution, which requires the coinfection of a single host cell with different SARS‐CoV‐2 strains. To understand the emergence and prevalence of… read more here.
Keywords: recombination among; recombination; immune escape; enhanced recombination ... See more keywords
Hypoxia-mediated down-regulation of miRNAs’ biogenesis promotes tumor immune escape in bladder cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02569-x
Abstract: The study examines the function of hypoxia-mediated down-regulation of microRNAs (miRNAs) (mir-30c, mir-135a, and mir-27a) in the process of bladder cancer immune escape. Quantitative Real-time PCR (qRT-PCR) was carried out to determine gene expression levels… read more here.
Keywords: bladder cancer; immune escape; expression; regulation ... See more keywords
α2,6-Sialylation promotes immune escape in hepatocarcinoma cells by regulating T cell functions and CD147/MMP signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-019-00674-8
Abstract: Altered glycosylation is a common feature of cancer cells and plays an important role in tumor progression. β-Galactoside α2-6-sialyltransferase 1 (ST6Gal-I) is the critical sialyltransferase responsible for the addition of α2-6-sialic acid to the terminal… read more here.
Keywords: escape hepatocarcinoma; escape; immune escape; promotes immune ... See more keywords
Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103355
Abstract: Background There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses. Methods… read more here.
Keywords: viral variants; infection; immune escape; sars cov ... See more keywords
LncRNA MALAT1 promotes tumorigenesis and immune escape of diffuse large B cell lymphoma by sponging miR-195.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.03.040
Abstract: BACKGROUND PD-L1 enhanced the tumorigenesis and immune escape abilities of cancers. The upstream mechanisms of PD-L1 in regulating tumorigenesis and immune escape of diffuse large B cell lymphoma (DLBCL) remained unclear. METHODS Human DLBCL cell… read more here.
Keywords: mir 195; tumorigenesis immune; malat1; immune escape ... See more keywords
Selection and Antigenic Characterization of Immune-Escape Mutants of H7N2 Low Pathogenic Avian Influenza Virus Using Homologous Polyclonal Sera.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198188
Abstract: Understanding the dynamics of the selection of influenza A immune escape variants by serum antibody is critical for designing effective vaccination programs for animals, especially poultry where large populations have a short generation time and… read more here.
Keywords: avian influenza; immune escape; virus; selection ... See more keywords
GATA3 Encapsulated by Tumor-Associated Macrophage-Derived Extracellular Vesicles Promotes Immune Escape and Chemotherapy Resistance of Ovarian Cancer Cells by Upregulating the CD24/Siglec-10 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00557
Abstract: Tumor-associated macrophages (TAMs) possess great potential in the development of ovarian cancer (OC). Aberrant GATA-binding protein-3 (GATA3) expression has been found in TAM-derived extracellular vesicles (EVs). This study is intended to investigate the regulatory mechanism… read more here.
Keywords: cd24 siglec; gata3; immune escape; resistance ... See more keywords
Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-021-02173-x
Abstract: Programmed death-ligand 1 (PD-L1) is an important immunosuppressive molecule highly expressed on the surface of cancer cells. IFNγ triggered cancer cell immunosuppression against CD8+ T cell surveillance via up-regulation of PD-L1. Histone demethylase JMJD2D promotes… read more here.
Keywords: cancer; tumor; jmjd2d; stat3 irf1 ... See more keywords