Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202937
Abstract: Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its… read more here.
Keywords: setd2 deficiency; immune escape; escape pancreatic; pancreatic tumorigenesis ... See more keywords
Targeting Nuclear Receptor Coactivator SRC‐1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD‐L1
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DOI: 10.1002/advs.202310037
Abstract: Programmed death‐ligand 1 (PD‐L1) is overexpressed in multiple cancers and critical for their immune escape. It has previously shown that the nuclear coactivator SRC‐1 promoted colorectal cancer (CRC) progression by enhancing CRC cell viability, yet… read more here.
Keywords: crc; immune escape; protein; expression ... See more keywords
Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg‐mediated immune escape of non‐small‐cell lung cancer cells through targeting the miR‐17‐5p/RUNX3 axis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23715
Abstract: Long noncoding RNA MIR17HG was involved with the progression of non‐small‐cell lung cancer (NSCLC), but specific mechanisms of MIR17HG‐mediated immune escape of NSCLC cells were still unknown. The present study investigated the function of MIR17HG… read more here.
Keywords: mir17hg; mediated immune; immune escape; cell ... See more keywords
CXCR4 up‐regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous‐cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70004
Abstract: CXC chemokine receptor 4 (CXCR4) and ubiquitin specific protease 1 (USP1) have been reported to involve in the tumorigenesis of esophageal squamous‐cell carcinoma (ESCC). Here, we investigated whether USP1 induced CXCR4 deubiquitination in regulating ESCC… read more here.
Keywords: deubiquitination; cxcr4; immune escape; cell ... See more keywords
GOT2 Elevation Mediated by YY1 Promotes the Tumorigenesis and Immune Escape of Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70256
Abstract: Glutamate‐oxaloacetate transaminase 2 (GOT2) has been demonstrated to contribute to lung cancer cell growth, invasion, migration and angiogenesis. Herein, we further probed the functions of GOT2 on lung adenocarcinoma (LUAD) cell ferroptosis and immune escape… read more here.
Keywords: lung; migration; immune escape; cell ... See more keywords
WTAP Promotes Malignant Progression and Immune Escape of Glioblastoma by Regulating N6‐methyladenosine Modification of CENPF
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DOI: 10.1002/jbt.70523
Abstract: Glioblastoma (GBM) is a malignant tumor. It has been shown that centromere protein F (CENPF) may serve as a potential prognostic biomarker for glioma patients, while Wilms' tumor 1‐associating protein (WTAP) is frequently upregulated across… read more here.
Keywords: cenpf; immune escape; gbm; progression immune ... See more keywords
The global epidemic of SARS-CoV-2 variants and their mutational immune escape.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27376
Abstract: During the COVID-19 pandemic, genetic variants of SARS-CoV-2 have been emerging and spreading around the world. Several SARS-CoV-2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and Apr-2021. Studies… read more here.
Keywords: epidemic sars; global epidemic; cov variants; immune escape ... See more keywords
The outbreak of SARS‐CoV‐2 Omicron lineages, immune escape, and vaccine effectivity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28138
Abstract: As of November 2021, several SARS‐CoV‐2 variants appeared and became dominant epidemic strains in many countries, including five variants of concern (VOCs) Alpha, Beta, Gamma, Delta, and Omicron defined by the World Health Organization during… read more here.
Keywords: omicron; immune escape; omicron lineages; outbreak sars ... See more keywords
Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28519
Abstract: Genetic recombination is an important driver of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) evolution, which requires the coinfection of a single host cell with different SARS‐CoV‐2 strains. To understand the emergence and prevalence of… read more here.
Keywords: recombination among; recombination; immune escape; enhanced recombination ... See more keywords
Immune escape of BA.2.86 is comparable to XBB subvariants from the plasma of BA.5‐ and BA.5‐XBB‐convalescent subpopulations
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29417
Abstract: The EG.5.1 variant of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has been prevalent since mid‐July 2023 in the United States and China. The variant BA.2.86 has become a major concern because it is 34 mutations… read more here.
Keywords: convalescent; escape comparable; immune escape; xbb subvariants ... See more keywords
Hypoxia-mediated down-regulation of miRNAs’ biogenesis promotes tumor immune escape in bladder cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02569-x
Abstract: The study examines the function of hypoxia-mediated down-regulation of microRNAs (miRNAs) (mir-30c, mir-135a, and mir-27a) in the process of bladder cancer immune escape. Quantitative Real-time PCR (qRT-PCR) was carried out to determine gene expression levels… read more here.
Keywords: bladder cancer; immune escape; expression; regulation ... See more keywords