Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion
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DOI: 10.1002/1873-3468.14623
Abstract: Tumor‐elicited inflammation confers tumorigenic properties, including cell death resistance, proliferation, or immune evasion. To focus on inflammatory signaling in tumors, we investigated linear ubiquitination, which enhances the nuclear factor‐κB signaling pathway and prevents extrinsic programmed… read more here.
Keywords: immune evasion; ubiquitination induced; linear ubiquitination; tumor ... See more keywords
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer
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DOI: 10.1002/advs.202203757
Abstract: The roles of oncogenic KRAS in tumor immune evasion remain poorly understood. Here, mutant KRAS is identified as a key driver of tumor immune evasion in colorectal cancer (CRC). In human CRC specimens, a significant… read more here.
Keywords: cell; immune evasion; mutant kras; colorectal cancer ... See more keywords
YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD‐L1/VEGFA Axis
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DOI: 10.1002/advs.202307242
Abstract: N6‐methyladenosine (m6A) modification orchestrates cancer formation and progression by affecting the tumor microenvironment (TME). For hepatocellular carcinoma (HCC), immune evasion and angiogenesis are characteristic features of its TME. The role of YTH N6‐methyladenosine RNA binding… read more here.
Keywords: ythdf2; immune evasion; hcc; evasion angiogenesis ... See more keywords
M6A‐mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8+ T cells and phagocytosis of macrophages
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DOI: 10.1002/advs.202400695
Abstract: Tumor immune evasion relies on the crosstalk between tumor cells and adaptive/innate immune cells. Immune checkpoints play critical roles in the crosstalk, and immune checkpoint inhibitors have achieved promising clinical effects. The long non‐coding RNA… read more here.
Keywords: tumor immune; cd8 cells; tug1; tumor ... See more keywords
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
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DOI: 10.1002/advs.202407575
Abstract: The immune evasion is one major challenge for cancer immunotherapy. Despite considerable advancements in immune checkpoint blockade (ICB) therapies for the advanced non‐small cell lung cancer (NSCLC) patients, only a minority of patients receive long‐term… read more here.
Keywords: cancer; lung cancer; progression; cancer progression ... See more keywords
Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma.
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DOI: 10.1002/advs.202510816
Abstract: Monocyte-derived cells, including osteoclasts, dendritic cells, and macrophages, are key components of the immunosuppressive tumor microenvironment in multiple myeloma (MM). However, the mechanisms linking monocyte dysfunction to immune evasion remain incompletely understood. In this study,… read more here.
Keywords: multiple myeloma; type; activation; type interferon ... See more keywords
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation
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DOI: 10.1002/cac2.70023
Abstract: Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and… read more here.
Keywords: novel molecular; molecular mechanisms; evasion; hepatocellular carcinoma ... See more keywords
m6A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma
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DOI: 10.1002/cac2.70052
Abstract: Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and… read more here.
Keywords: m6a modified; immune evasion; evasion immunotherapy;
UBD‐mediated glycolytic reprogramming promotes M2 macrophage polarization in ovarian cancer immune evasion
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DOI: 10.1002/ccs3.70034
Abstract: Ovarian cancer (OC) is one of the most common malignant tumors in women, with immunotherapy resistance (ITR) being a major challenge. Glycolytic metabolic reprogramming has been shown to play a crucial role in the tumor… read more here.
Keywords: polarization; immune evasion; ovarian cancer; macrophage polarization ... See more keywords
Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion
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DOI: 10.1002/jmv.28478
Abstract: Patients with severe COVID‐19 often suffer from lymphopenia, which is linked to T‐cell sequestration, cytokine storm, and mortality. However, it remains largely unknown how severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) induces lymphopenia. Here, we… read more here.
Keywords: immune evasion; cov promotes; promotes immune; infected cells ... See more keywords
Advances in KSHV Research: Molecular Pathogenesis, Immune Evasion, and Evolving Therapeutic Horizon
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DOI: 10.1002/jmv.70695
Abstract: Kaposi's sarcoma–associated herpesvirus (KSHV/HHV‐8) infects more than 140 million people worldwide, with transmission occurring mainly through saliva, blood transfusion, and sexual contact. Despite its global burden, especially in HIV‐endemic regions, KSHV‐related diseases remain underdiagnosed and… read more here.
Keywords: research; immune evasion; pathogenesis; advances kshv ... See more keywords