Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04057-2
Abstract: Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)1. The extracellular matrix (ECM) contributes to immune exclusion2. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4.… read more here.
Keywords: exclusion; immune exclusion; fibre alignment; collagen fibre ... See more keywords
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001772
Abstract: Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective. The mechanisms that prevent successful immunotherapy in osteosarcoma are incompletely understood. We investigated the tumor microenvironment of metastatic osteosarcoma with the goal of harnessing the… read more here.
Keywords: metastatic osteosarcoma; immune exclusion; osteosarcoma; patient outcomes ... See more keywords
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.604967
Abstract: In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is… read more here.
Keywords: generation imaging; solid tumors; immune exclusion; immune topographies ... See more keywords
Galectins as pivotal components in oncogenesis and immune exclusion in human malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1145268
Abstract: Galectins are galactoside-binding proteins, exerting numerous functions inside and outside the cell, particularly conferring adaptation to stress factors. For most of them, aberrant expression profiles have been reported in the context of cancer. Albeit not… read more here.
Keywords: galectins pivotal; components oncogenesis; immune exclusion; exclusion ... See more keywords
A Novel Computational Framework for Predicting the Survival of Cancer Patients With PD-1/PD-L1 Checkpoint Blockade Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.930589
Abstract: Background Immune checkpoint inhibitors (ICIs) induce durable responses, but only a minority of patients achieve clinical benefits. The development of gene expression profiling of tumor transcriptomes has enabled identifying prognostic gene expression signatures and patient… read more here.
Keywords: immune exclusion; predicting survival; framework predicting; therapy ... See more keywords