Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04057-2
Abstract: Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)1. The extracellular matrix (ECM) contributes to immune exclusion2. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4.… read more here.
Keywords: exclusion; immune exclusion; fibre alignment; collagen fibre ... See more keywords
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001772
Abstract: Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective. The mechanisms that prevent successful immunotherapy in osteosarcoma are incompletely understood. We investigated the tumor microenvironment of metastatic osteosarcoma with the goal of harnessing the… read more here.
Keywords: metastatic osteosarcoma; immune exclusion; osteosarcoma; patient outcomes ... See more keywords
Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-010787
Abstract: Background Lung adenocarcinoma (LUAD) presents significant challenges in prognosis and treatment efficacy evaluation. While post-translational modifications are known to influence tumor progression, their prognostic value in LUAD remains largely unexplored. Methods We developed a post-translational… read more here.
Keywords: immune exclusion; signature; post translational; luad ... See more keywords
Abstract 7392: Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7392
Abstract: Background: Immune exclusion is characterized by a predominance of CD8+ T cells in the stroma of the tumor microenvironment (TME) which are not in contact with tumor cells. Immune exclusion is a significant obstacle to… read more here.
Keywords: cancer; cd8; immune exclusion; tumor ... See more keywords
Abstract 3851: Vascular regulation of immune exclusion in melanoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3851
Abstract: The infiltration of immune cells into the tumor is as crucial as their activity in determining the responses to immune checkpoint inhibitors (ICIs). Immune cell exclusion from tumors has been linked to poor responses to… read more here.
Keywords: immune exclusion; melanoma; cell; tumor ... See more keywords
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.604967
Abstract: In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is… read more here.
Keywords: generation imaging; solid tumors; immune exclusion; immune topographies ... See more keywords
Galectins as pivotal components in oncogenesis and immune exclusion in human malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1145268
Abstract: Galectins are galactoside-binding proteins, exerting numerous functions inside and outside the cell, particularly conferring adaptation to stress factors. For most of them, aberrant expression profiles have been reported in the context of cancer. Albeit not… read more here.
Keywords: galectins pivotal; components oncogenesis; immune exclusion; exclusion ... See more keywords
A Novel Computational Framework for Predicting the Survival of Cancer Patients With PD-1/PD-L1 Checkpoint Blockade Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.930589
Abstract: Background Immune checkpoint inhibitors (ICIs) induce durable responses, but only a minority of patients achieve clinical benefits. The development of gene expression profiling of tumor transcriptomes has enabled identifying prognostic gene expression signatures and patient… read more here.
Keywords: immune exclusion; predicting survival; framework predicting; therapy ... See more keywords
Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Vaccines"
DOI: 10.3390/vaccines12010063
Abstract: Colorectal cancer (CRC) currently ranks as the third most common cancer in the United States, and its incidence is on the rise, especially among younger individuals. Despite the remarkable success of immune checkpoint inhibitors (ICIs)… read more here.
Keywords: cancer; immune checkpoint; crc; immune exclusion ... See more keywords