A novel tailored immune gene pairs signature for overall survival prediction in lower-grade gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101109
Abstract: Highlights • The Immune-related gene pairs (IRGPs) pronostic signature for LGG is correlated with immune cells infiltration.• WGCNA presented a gene set correlating with immune cells infiltration and genes co-expression relationships were visualized.• The nomogram… read more here.
Keywords: tailored immune; gene pairs; novel tailored; immune gene ... See more keywords
Detangling the mechanisms and timing of MHC-dependent sexual selection using Soay sheep.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular ecology"
DOI: 10.1111/mec.16255
Abstract: Immune defense is a key component of fitness and individuals are expected to have evolved preferences for mates that ensure immunocompetent offspring. Potential preferences include those for mates with specific heritable immune gene profiles ('good… read more here.
Keywords: soay sheep; selection; sexual selection; immune gene ... See more keywords
Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii)
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16408
Abstract: Understanding the effects of wildlife diseases on populations requires insight into local environmental conditions, host defence mechanisms, host life‐history trade‐offs, pathogen population dynamics, and their interactions. The survival of Tasmanian devils (Sarcophilus harrisii) is challenged… read more here.
Keywords: immune gene; expression; sarcophilus harrisii; cancer ... See more keywords
circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2214686
Abstract: Background Immunotherapy is an important treatment modality for gastric cancer, therefore, it is crucial to understand the regulators of the tumor microenvironment in gastric cancer. Numerous studies have shown that noncoding RNAs have a critical… read more here.
Keywords: gene signature; cancer; immune gene; gastric cancer ... See more keywords
Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II–III Melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-2847
Abstract: Purpose: Biomarkers are needed to stratify patients with stage II–III melanoma for clinical trials of adjuvant therapy because, while immunotherapy is protective, it also confers the risk of severe toxicity. We previously defined and validated… read more here.
Keywords: immune gene; stage iii; mip; melanoma ... See more keywords
Abstract 4070: Development of MAEGI as a new class of immune gene therapy for cancer treatment
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4070
Abstract: Current major types of immunotherapy include checkpoint blockade, adoptive cell transfer, human recombinant cytokines, and cancer vaccines. However, immunotherapy has met challenges in immunologically cold tumors. These challenges urge for new types of immunotherapies that… read more here.
Keywords: treatment; gene therapy; immune gene; cancer ... See more keywords
Development and validation of a five-immune gene prognostic risk model in colon cancer
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-06799-0
Abstract: Background Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to… read more here.
Keywords: five immune; model; colon cancer; immune gene ... See more keywords
Immune gene profiling of pretreatment tumor samples in "real-world" advanced melanoma patients treated with anti-PD-1 and/or anti-CTLA-4.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.9585
Abstract: 9585Background: The immune checkpoint inhibitors (CI) anti-CTLA-4 (ipilimumab [IPI]) and anti-PD-1 (pembrolizumab [PEM] and nivolumab [NIVO]) have improved survival in advanced melanoma patients (p... read more here.
Keywords: anti ctla; advanced melanoma; gene profiling; profiling pretreatment ... See more keywords
Immune gene signatures and integrative spatially-resolved digital profiling of prognostic biomarkers for mesothelioma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e20071
Abstract: e20071 Background: Malignant mesothelioma has been an incurable disease with few effective therapies. While PD-1 targeted therapies have elicited some patient responses, the overall response rate for mesothelioma is low. Since mesothelioma is derived from… read more here.
Keywords: expression; immune gene; gene signatures; profiling ... See more keywords
Comprehensive immune transcriptomic analysis in bladder cancer reveals subtype specific immune gene expression patterns of prognostic relevance
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20237
Abstract: Recent efforts on genome wide profiling of muscle invasive bladder cancer (MIBC) have led to its classification into distinct genomic and transcriptomic molecular subtypes that exhibit variability in prognosis. Evolving evidence from recent immunotherapy trials… read more here.
Keywords: cancer; expression patterns; immune gene; gene expression ... See more keywords
An Immune Gene-Related Five-lncRNA Signature for to Predict Glioma Prognosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.612037
Abstract: Background The tumor immune microenvironment is closely related to the malignant progression and treatment resistance of glioma. Long non-coding RNA (lncRNA) plays a regulatory role in this process. We investigated the pathological mechanisms within the… read more here.
Keywords: glioma; prognosis; gene related; immune gene ... See more keywords