Immune genes outside immune cells for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2022.03.017
Abstract: In this issue of Neuron, Meijer and Agirre et al. (2022) demonstrate that immune genes exhibit a primed chromatin state in healthy oligodendroglia and are transcriptionally activated in MS through a series of epigenetic activations including… read more here.
Keywords: cells multiple; outside immune; immune genes; multiple sclerosis ... See more keywords
Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
Sign Up to like & getrecommendations! Published in 2018 at "Nature Genetics"
DOI: 10.1038/s41588-018-0298-2
Abstract: Accumulation of trimethylation of histone H3 at lysine 4 (H3K4me3) on immune-related gene promoters underlies robust transcription during trained immunity. However, the molecular basis for this remains unknown. Here we show three-dimensional chromatin topology enables… read more here.
Keywords: transcription; long noncoding; genes primed; noncoding rnas ... See more keywords
Signatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1937910
Abstract: In recent years, genes associated with N6-methyladenosine (m6A) modification were found to participate in modulation of multiple tumor biological processes. Concomitantly, the significantly complicated dual effects of tumor microenvironment have been observed on cancer progression.… read more here.
Keywords: methyladenosine m6a; m6a related; cancer; immune genes ... See more keywords
Signatures of Adaptation, Constraints, and Potential Redundancy in the Canonical Immune Genes of a Key Pollinator
Sign Up to like & getrecommendations! Published in 2023 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evad039
Abstract: Abstract All organisms require an immune system to recognize, differentiate, and defend against pathogens. From an evolutionary perspective, immune systems evolve under strong selective pressures exerted by fast-evolving pathogens. However, the functional diversity of the… read more here.
Keywords: pollinator; immune genes; immune; immune system ... See more keywords
The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evad044
Abstract: The pressure to survive relentless pathogen exposure explains the frequent observation that immune genes are among the fastest-evolving in the genomes of many taxa, but an intriguing proportion of immune genes also appear to be… read more here.
Keywords: immune genes; pleiotropic immune; developmental pleiotropy; pleiotropy ... See more keywords
Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac102
Abstract: Abstract Balancing selection is a classic mechanism for maintaining variability in immune genes involved in host–pathogen interactions. However, it remains unclear how widespread the mechanism is across immune genes other than the major histocompatibility complex… read more here.
Keywords: toll like; immune genes; balancing selection; innate immune ... See more keywords
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab500
Abstract: Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures involved in fundamental biological processes. As G4s are promising anticancer targets, in past decades the search for effective anticancer G4 binders aimed at the discovery of more… read more here.
Keywords: quadruplex binders; binders cytostatic; cancer cells; cancer ... See more keywords
Complex patterns shape immune genes diversity during invasion of common raccoon in Europe – Selection in action despite genetic drift
Sign Up to like & getrecommendations! Published in 2022 at "Evolutionary Applications"
DOI: 10.1111/eva.13517
Abstract: Rapid adaptation is common in invasive populations and is crucial to their long‐term success. The primary target of selection in the invasive species' new range is standing genetic variation. Therefore, genetic drift and natural selection… read more here.
Keywords: raccoon; immune genes; diversity; invasion ... See more keywords
Understanding the evolution of immune genes in jawed vertebrates.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of evolutionary biology"
DOI: 10.1111/jeb.14181
Abstract: Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation… read more here.
Keywords: evolution immune; genes jawed; immune genes; understanding evolution ... See more keywords
A targeted approach to investigating immune genes of an iconic Australian marsupial
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16493
Abstract: Disease is a contributing factor to the decline of wildlife populations across the globe. Koalas, iconic yet declining Australian marsupials, are predominantly impacted by two pathogens, Chlamydia and koala retrovirus. Chlamydia is an obligate intracellular… read more here.
Keywords: immune genes; disease; chlamydia; disease progression ... See more keywords
Development of an Individualized Immune Prognostic Signature for Clear Cell Renal Cell Carcinoma through the Identification of Differential Immune Genes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology"
DOI: 10.1155/2021/9587084
Abstract: Increasing evidence has shown that tumor microenvironments are an important feature in clear cell renal cell carcinoma (ccRCC) carcinogenesis and therapeutic efficacy. In this study, two subtypes of ccRCC, high- and low-immune groups, were identified… read more here.
Keywords: cell renal; renal cell; cell carcinoma; cell ... See more keywords