Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005809
Abstract: Background Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers where a primary tissue of origin (TOO) is uncertain. Most patients with CUP have limited treatment options and poor survival outcomes. Immune… read more here.
Keywords: unknown primary; patients cup; immune genomic; cancer unknown ... See more keywords
Abstract 4545: Integrative immune-genomic comparison of canonical Ewing sarcoma with Ewing-like mimics identifies potential targets for personalized therapies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4545
Abstract: Introduction: Ewing sarcoma (ES) is one of the most common types of small round cell sarcoma (SRCS) from the skeletal origin, characterized by small round blue cell morphology and FET-ETS fusions. However, recent NGS-based technology… read more here.
Keywords: fet ets; srcs; immune genomic; ewing sarcoma ... See more keywords
Deciphering immune-genomic markers of hyperprogression in patients (Pts) with metastatic urothelial cancer (mUC) treated with immune checkpoint inhibitors (ICIs).
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.5_suppl.840
Abstract: 840 Background: ICIs offer modest response rates (~20%) in mUC and there remains a critical need for validated biomarkers to predict patient benefit. Hyperprogressive disease (HPD), characterized by rapid tumor progression following ICI initiation, is… read more here.
Keywords: immune genomic; muc treated; analysis; hpd ... See more keywords
Adjusted CT Image-Based Radiomic Features Combined with Immune Genomic Expression Achieve Accurate Prognostic Classification and Identification of Therapeutic Targets in Stage III Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081895
Abstract: Simple Summary Using the covariate-adjusted tensor classification in the high-dimension (CATCH) model, we integrated adjusted radiomics-based CT images into RNA immune genomic expression data to achieve the accurate classification of recurrent CRC. The correlation between… read more here.
Keywords: immune genomic; adjusted radiomic; expression; genomic expression ... See more keywords