Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma
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DOI: 10.1158/0008-5472.can-22-2589
Abstract: Intratumoral immune hotspots beyond tertiary lymphoid structures reflect an immunosuppressive microenvironment, different from peritumoral immune hotspots, warranting further study in the context of immunotherapies. read more here.
Keywords: immune hotspots; positioning immune; reflects interplay; spatial positioning ... See more keywords
Resolving the Microarchitecture of Classic and Transformed Follicular Lymphoma By Single Cell Alignment to Spatial Transcriptomes
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DOI: 10.1182/blood-2024-199300
Abstract: Background: Despite significant advances in single-cell and bulk transcriptome profiling of classic and transformed follicular lymphomas (FL), their tumor microenvironments remain insufficiently understood, limiting the discovery of treatment strategies that target local survival niches. The… read more here.
Keywords: immune hotspots; classic transformed; microarchitecture; single cell ... See more keywords