Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2737-9
Abstract: There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar adult tumors and its correlation with survival. Here, we provide a… read more here.
Keywords: pediatric brain; immune infiltrate; brain tumors; histology ... See more keywords
Tumour immune infiltrate characterization in luminal breast cancer in three distinct age categories and its correlation with frailty
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz452.004
Abstract: Abstract Background Immunosenescence, the age-related decrease in immune competence, is characterized by decreased adaptive immunity and increased low-grade inflammation. This may lead to altered anti-tumor immune responses and thus affect tumor immune infiltrate in older… read more here.
Keywords: age; immune infiltrate; infiltrate characterization; cancer ... See more keywords
SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-1726
Abstract: Purpose: SMAD4 has shown promise in identifying patients with colorectal cancer at high risk of recurrence or death. Experimental Design: A discovery cohort and independent validation cohort were classified by SMAD4 status. SMAD4 status and… read more here.
Keywords: colorectal cancer; immune infiltrate; smad4 loss; loss ... See more keywords
The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-1749
Abstract: Purpose: The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood. Experimental Design: We applied high-dimensional single-cell mass cytometry [Cytometry by… read more here.
Keywords: etiology; cd161 effector; immune infiltrate; cervical carcinoma ... See more keywords
Integrating Tumor-Intrinsic and Immunologic Factors to Identify Immunogenic Breast Cancers from a Low-Risk Cohort: Results from the Randomized SweBCG91RT Trial
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-2746
Abstract: Abstract Purpose: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk cohort… read more here.
Keywords: immune infiltrate; breast; factors identify; risk ... See more keywords
Abstract 5955: In Silico dissection of immune infiltrate signatures that are detected by DetermaIO, a predictor of response to immune therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5955
Abstract: Background: The composition of tumors includes not only malignant but also immune, stromal and other cell types. Understanding this dynamic tumor immune microenvironment (TIME) is important to guide treatment and develop novel therapies and markers.… read more here.
Keywords: immune infiltrate; infiltrate signatures; cell; expression ... See more keywords
Adaptive transcriptomic and immune infiltrate responses in the tumor immune microenvironment following neoadjuvant chemotherapy in high grade serous ovarian cancer reveal novel prognostic associations and activation of pro-tumorigenic pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.965331
Abstract: The high rate of ovarian cancer recurrence and chemoresistance necessitates further research into how chemotherapy affects the tumor immune microenvironment (TIME). While studies have shown that immune infiltrate increases following neoadjuvant (NACT) chemotherapy, there lacks… read more here.
Keywords: immune infiltrate; ovarian cancer; chemotherapy; tumor immune ... See more keywords
Leukocytic Infiltration of Intraductal Carcinoma of the Prostate: An Exploratory Study
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DOI: 10.3390/cancers15082217
Abstract: Simple Summary Men with a particular type of prostate cancer, called intraductal carcinoma of the prostate (IDC-P), are more likely to die from their cancer than men without IDC-P. No researchers have yet compared the… read more here.
Keywords: immune infiltrate; prostate; intraductal carcinoma; idc ... See more keywords