The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.214
Abstract: Immune dysfunctions in chronic lymphocytic leukemia (CLL) contribute to tumor immune escape and attenuate immune-based therapies. Monocytes/macrophages represent key components of cancer immune surveillance and effectors for antibody-mediated antitumor effects. Monocytes display an altered subset… read more here.
Keywords: immune metabolic; cll; lymphocytic leukemia; metabolic dysfunctions ... See more keywords
Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207544120
Abstract: Significance Humans have adapted to diverse environments, but few studies have linked regions of the genome with evidence of selection to phenotypes. We generated an integrative dataset of genomic, transcriptomic, and biomarker data for the… read more here.
Keywords: selection immune; genes associated; metabolic genes; natural selection ... See more keywords
A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2073131
Abstract: ABSTRACT Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated clinical sequelae requires well-coordinated metabolic and immune responses that limit viral spread and promote recovery of damaged systems. However, the role of… read more here.
Keywords: responses sars; immune metabolic; sars cov; gut microbiota ... See more keywords
Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170101
Abstract: Regulation of microRNA (miRNA) expression contributes to a wide range of target gene expression and phenotypes. The miRNA expression in the liver, the central metabolic organ, was examined in 209 pigs, and integrated with haematological… read more here.
Keywords: immune metabolic; mirna; mir; expression levels ... See more keywords
From decidualization to pregnancy progression: An overview of immune and metabolic effects of VIP
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13601
Abstract: A tight immune and metabolic regulation underlies the early maternal‐placental interaction to assist the energetic dynamic demands of the fetus throughout pregnancy. The vasoactive intestinal peptide (VIP) holds biochemical, metabolic and immune properties consistent with… read more here.
Keywords: decidualization pregnancy; progression overview; pregnancy progression; pregnancy ... See more keywords
Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0244
Abstract: The computational tool BipotentR was used to reveal drug targets that can inhibit tumor growth by concurrent immune activation and inhibition of a separate oncogenic pathway, leading to identification of ESRRA as a top immune–metabolic… read more here.
Keywords: discovery targets; immune metabolic; targets immune; metabolic antitumor ... See more keywords
Identification of immune and metabolic predictors of severe hand-foot-mouth disease
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0216993
Abstract: Hand, foot and mouth disease (HFMD) is an infectious disease that affects mostly children. The children with HFMD also have other immune and metabolic disorders. However, the association of these disorders with the severity of… read more here.
Keywords: hfmd; immune metabolic; severe hfmd; disease ... See more keywords
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0728
Abstract: Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, prevents diabetes, and… read more here.
Keywords: cell; immunotherapy; type diabetes; diabetes immune ... See more keywords
Transcription Factors Interplay Orchestrates the Immune-Metabolic Response of Leishmania Infected Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.660415
Abstract: Leishmaniasis is a group of heterogenous diseases considered as an important public health problem in several countries. This neglected disease is caused by over 20 parasite species of the protozoa belonging to the Leishmania genus… read more here.
Keywords: immune metabolic; response; metabolic response; transcription factors ... See more keywords
Multi-Omics Reveals Different Strategies in the Immune and Metabolic Systems of High-Yielding Strains of Laying Hens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.858232
Abstract: Lohmann Brown (LB) and Lohmann Selected Leghorn (LSL) are two commercially important laying hen strains due to their high egg production and excellent commercial suitability. The present study integrated multiple data sets along the genotype-phenotype… read more here.
Keywords: multi omics; omics reveals; immune metabolic; systems high ... See more keywords
Blood transcriptome reveals immune and metabolic-related genes involved in growth of pasteurized colostrum-fed calves
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1075950
Abstract: The quality of colostrum is a key factor contributing to healthy calf growth, and pasteurization of colostrum can effectively reduce the counts of pathogenic microorganisms present in the colostrum. Physiological changes in calves fed with… read more here.
Keywords: colostrum; growth pasteurized; immune metabolic; pasteurized colostrum ... See more keywords